Repository logo
 
Publication

Intraocular lens opacification after Descemet’s membrane endothelial keratoplasty: risk factors and outcomes after intraocular lens exchange

2025-06Journal article Embargoed access
Simple item page
dc.contributor.authorMoura-Coelho, Nuno
dc.contributor.authorPapa-Vettorazzi, Renato
dc.contributor.authorReyes, Alonso
dc.contributor.authorCunha, João Paulo
dc.contributor.authorDutra-Medeiros, Marco
dc.contributor.authorManero, Felicidad
dc.contributor.authorGüell, José Luis
dc.date.accessioned2024-08-28T11:42:41Z
dc.date.embargo2026-08-28
dc.date.issued2025-06
dc.description.abstractPurpose: To determine risk factors for intraocular lens opacification (IOLop) after Descemet membrane endothelial keratoplasty (DMEK) and to analyze clinical outcomes after IOL exchange. Methods: Cross-Sectional Study: Analysis of all cases of IOL exchange because of post-DMEK IOLop with a minimum of 6-month postoperative follow-up observed in the clinic between November 2021 and April 2022. The main outcomes analyzed at the study visit were changes in the logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity after IOL exchange, endothelial cell loss (ECL), and graft survival. A historical cohort of 232 pseudophakic DMEK eyes was retrospectively analyzed to determine risk factors for post-DMEK IOLop. Results: Cross-Sectional Study: Four eyes were observed (median follow-up = 45 (35.5-86.8) months). IOL materials were hydrophilic acrylic IOLs in 2 eyes and hydrophobic-hydrophilic in the other 2. At the study visit, improvement in median best-corrected visual acuity after IOL exchange was statistically significant (0.25 (0.19-0.41) logMAR to 0.00 (0-0.10) logMAR; P = 0.041). ECL ranged between 57.7% and 85.3%, without cases of graft failure. In the historical cohort, 21 eyes (9.05%) had some IOLop. In the multivariate logistic regression model (105 eyes where IOL material data was available), IOLs with high water content material (odds ratio = 65.5, P = 0.0005) and rebubbling (odds ratio = 9.51, P = 0.0138) were independent risk factors for post-DMEK IOLop. Conclusions: Post-DMEK IOLop is infrequent, but a non-neglectable proportion of cases may require IOL explantation. IOL exchange is safe and effective in these eyes but may pose a risk for increased ECL. This study confirms that IOL material and the number of rebubblings are major risk factors for post-DMEK IOLop.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoura-Coelho N, Papa-Vettorazzi R, Reyes A, Cunha JP, Dutra-Medeiros M, Manero F, et al. Intraocular lens opacification after Descemet’s membrane endothelial keratoplasty: risk factors and outcomes after intraocular lens exchange. Cornea. 2025;44(6):720-5.pt_PT
dc.identifier.doi10.1097/ICO.0000000000003649pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17632
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherLippincott Williams & Wilkinspt_PT
dc.relation.publisherversionhttps://journals.lww.com/corneajrnl/abstract/9900/intraocular_lens_opacification_after_descemet_s.643.aspxpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOphthalmologypt_PT
dc.subjectDescemet membranept_PT
dc.subjectEndothelial keratoplastypt_PT
dc.subjectIntraocular lens opacificationpt_PT
dc.subjectRisk factorpt_PT
dc.titleIntraocular lens opacification after Descemet’s membrane endothelial keratoplasty: risk factors and outcomes after intraocular lens exchangept_PT
dc.typejournal article
degois.publication.firstPage720
degois.publication.issue6
degois.publication.lastPage725
degois.publication.volume44
dspace.entity.typePublication
oaire.citation.titleCorneapt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Intraocular lens opacification after Descemet’s membrane endothelial keratoplasty_risk factors and outcomes after intraocular lens exchange.pdf
Size:
309.14 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos