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Epigenetic mechanisms in the regulation of lymphocyte differentiation

2020-06Book part Restricted access
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dc.contributor.authorSchmolka, Nina
dc.contributor.authorSilva-Santos, Bruno
dc.contributor.authorGomes, Anita Q.
dc.date.accessioned2020-07-29T09:19:03Z
dc.date.available2020-07-29T09:19:03Z
dc.date.issued2020-06
dc.description.abstractEpigenetics refers to heritable phenotype changes that do not involve alterations in the DNA sequence. While DNA methylation and histone modifications represent the classical epigenetic mechanisms, RNA-based interference can also be integrated into the epigenetic machinery. In particular, microRNAs play important roles in regulating gene expression at the posttranscriptional level. Thus, from the nucleus to the cytoplasm, various “epigenetic” mechanisms can control cell fate decisions and differentiation. This has been extensively documented in lymphocyte biology, from a commitment to the B- and T-cell lineages to the differentiation of multiple effector lymphocyte subsets. Here we review the accumulated knowledge that fundaments our understanding of how classical epigenetics and RNA-based regulatory mechanisms impact B- and T-cell differentiation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSchmolka N, Silva-Santos B, Gomes AQ. Epigenetic mechanisms in the regulation of lymphocyte differentiation. In: Kabelitz D, Bhat J, editors. Epigenetics of the immune system. San Diego: Academic Press; 2020. p. 77-116.pt_PT
dc.identifier.doi10.1016/B978-0-12-817964-2.00004-6pt_PT
dc.identifier.isbn9780128179642
dc.identifier.urihttp://hdl.handle.net/10400.21/12109
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAcademic Presspt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/B9780128179642000046pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectChromatinpt_PT
dc.subjectHistone methylationpt_PT
dc.subjectDNA methylationpt_PT
dc.subjectlncRNAspt_PT
dc.subjectmiRNAspt_PT
dc.subjectT-cell differentiationpt_PT
dc.subjectB-cell differentiationpt_PT
dc.subjectGene expression regulationpt_PT
dc.titleEpigenetic mechanisms in the regulation of lymphocyte differentiationpt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage116pt_PT
oaire.citation.startPage77pt_PT
person.familyNameGomes
person.givenNameAnita
person.identifier.ciencia-id4B10-E015-52B7
person.identifier.orcid0000-0002-3348-0448
person.identifier.ridC-3580-2014
person.identifier.scopus-author-id7202386033
rcaap.rightsrestrictedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublication2b5a3f0a-29c2-4ecd-a83f-50d0b99a4875
relation.isAuthorOfPublication.latestForDiscovery2b5a3f0a-29c2-4ecd-a83f-50d0b99a4875

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