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Sarcopenia in liver transplant due to familial amyloidotic polyneuropathy (FAP): the relevance of muscle mass

2017-12Conference object Open access
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dc.contributor.authorTomás, Maria Teresa
dc.contributor.authorMelo, Xavier
dc.contributor.authorMateus, Élia
dc.contributor.authorBarroso, Eduardo
dc.contributor.authorSanta-Clara, Helena
dc.date.accessioned2017-12-18T16:22:06Z
dc.date.available2017-12-18T16:22:06Z
dc.date.issued2017-12
dc.descriptionEste trabalho foi financiado pelo Concurso Anual para Projetos de Investigação, Desenvolvimento, Inovação e Criação Artística (IDI&CA) 2016 do Instituto Politécnico de Lisboa. Código de referência: IPL/2016/SFQ2017_ESTeSLpt_PT
dc.description.abstractIntroduction: Loss of muscle mass and function is a common occurrence in liver transplant Familial Amyloidotic Polyneuropathy (FAP) patients. Sarcopenia is associated with morbidity and mortality before and after liver transplantation. However, the ability of skeletal muscle mass to recover after transplant remains questionable and thus the importance of clinical exercise prescription. Methods: Participants were 39 FAP patients aged 23-59 years, who had been submitted to a liver transplant (Tx) (22 men) between 2 and 4 months post-tx. Sarcopenia was defined according to the International Working Group on Sarcopenia and Society of Sarcopenia, Cachexia, and Wasting Disorders. Whole-body dual x-ray absorptiometry was used to measure body fat and lean-soft tissue. Skeletal Muscle Index (SMI) was calculated adjusting the value of appendicular skeletal mass to the squared height. Functional aerobic capacity was assessed using the 6 min walk test (6MWT), and handgrip strength were measured on the dominant hand using a hand dynamometer. Results: The prevalence of sarcopenia using SMI was 45.5% in men and 41.2% in women. A fat mass higher than 16% for men and 26% for women was found in 54.5% of men and 52.9% of women. Also, 27.3% of men and 17.6% of the women could be classified as having sarcopenia with low mobility (distance < 400 m). Discussion and Conclusions: Sarcopenia is common in FAP patients and a liver transplant seems to increase the prevalence, also because an aggressive medication with impact on muscle metabolism should be made longtime. More data are needed on the long-term effects of sarcopenia after transplant, especially in light of the high rate of metabolic syndrome. A clinical exercise prescription seems to be necessary for these patients but more studies are needed (e.g. longitudinal studies).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTomás MT, Melo X, Mateus E, Barroso E, Santa-Clara H. Sarcopenia in liver transplant due to familial amyloidotic polyneuropathy (FAP): the relevance of muscle mass. In: 10th International Conference on Cachexia, Sarcopenia & Muscle Wasting, Sheraton Roma Hotel and Conference Center, Rome (Italy), 8-10 December 2017. J Cachexia Sarcopenia Muscle. 2017;8(6):1021.pt_PT
dc.identifier.doi10.1002/jcsm.12255pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/7717
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/jcsm.12255/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPhysiotherapypt_PT
dc.subjectRehabilitationpt_PT
dc.subjectSarcopeniapt_PT
dc.subjectFamilial amyloidotic polyneuropathypt_PT
dc.subjectLiver transplantpt_PT
dc.subjectIPL/2016/SFQ2017_ESTeSLpt_PT
dc.titleSarcopenia in liver transplant due to familial amyloidotic polyneuropathy (FAP): the relevance of muscle masspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage1021pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1021pt_PT
oaire.citation.titleJournal of Cachexia, Sarcopenia and Musclept_PT
oaire.citation.volume8pt_PT
person.familyNameTomás
person.givenNameMaria Teresa
person.identifier438585
person.identifier.ciencia-id3010-19D6-C7A5
person.identifier.orcid0000-0003-0491-8903
person.identifier.ridN-1940-2013
person.identifier.scopus-author-id36700434200
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication64ad74a4-4cd4-426e-a1ee-2ec846fdc6dd
relation.isAuthorOfPublication.latestForDiscovery64ad74a4-4cd4-426e-a1ee-2ec846fdc6dd

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