TBCCD1 and OFD1, a novel centrosomal protein partnership with a role in human ciliopathies?

Veiga, Joaquim; Carmona, Bruno; Camelo, Carolina; Pereira, Dulce; Marinho, H. Susana; Soares, Helena

http://hdl.handle.net/10400.21/7303

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Abstract(s)

Cilia are hair-like appendages, consisting of a microtubule (MT)-based ciliary axoneme, that fulfill critical motility and sensory functions required for normal embryonic development and also for homeostasis of adult tissues. At their base, cilia have a centriole/basal body, which can be derived from the centrosome, and that nucleates the ciliary axoneme (primary cilia). Centrosomes consist of a pair of centrioles surrounded by the pericentriolar matrix that nucleate/organize the cytoskeleton and are implicated in cell migration, adhesion and polarity, while in mitosis they assist spindle pole formation.

Description

Este trabalho foi financiado pelo Concurso Anual para Projetos de Investigação, Desenvolvimento, Inovação e Criação Artística (IDI&CA) 2016 do Instituto Politécnico de Lisboa. Código de referência: IPL/2016/TBCCentro_ESTeSL

Keywords

TBCCD1 OFD1 Human ciliopathies IPL/2016/TBCCentro_ESTeSL

URI

http://hdl.handle.net/10400.21/7303

Citation

Veiga J, Carmona B, Camelo C, Pereira D, Marinho HS, Soares H. TBCCD1 and OFD1, a novel centrosomal protein partnership with a role in human ciliopathies?. In CQB day 2017, FCUL, May 31st 2017.