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Using less than 10% formalin fixed tissue samples in vimentin histochemical detection: possible impact on oncobiological analysis?

2020-01Conference object Open access
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dc.contributor.authorGraça-Lopes, Raquel
dc.contributor.authorAlmeida, Mariana
dc.contributor.authorPalma, João
dc.contributor.authorMaia-Matos, Mário
dc.contributor.authorLadeira, Carina
dc.contributor.authorFerro, Amadeu Borges
dc.date.accessioned2020-05-26T19:10:49Z
dc.date.available2020-05-26T19:10:49Z
dc.date.issued2020-01
dc.description.abstractThere are very few circumstances where the diagnosis of malignancy is made in the absence of histopathological confirmation. For prognosis and therapeutic guidance, it is also essential to support all decisions with knowledge of the oncobiology provided by immunohistochemistry and other molecular methodologies. Regarding this goal, it is essential to obtain/preserve adequate diagnostic material. In case of tissue samples, the most widely used fixative is 10 neutral buffered formalin 4 However, this concentration is not supported by consistent scientific evidence. Aim of the study: To compare immunohistochemical results considering less than 10 formalin concentrations, in order to support the proper use of this reagent and also to explore the possibility of decreasing the formalin use, since its toxicity is known.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGraça-Lopes R, Almeida M, Palma J, Maia-Matos M, Ladeira C, Ferro AB. Using less than 10% formalin fixed tissue samples in vimentin histochemical detection: possible impact on oncobiological analysis? In: Seminário CIMAGO - Desafios em Oncologia, Faculdade de Medicina da Universidade de Coimbra, 30 de janeiro de 2020.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/11729
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.uc.pt/fmuc/cimago/cursos/seminario_cimagopt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOncobiologypt_PT
dc.subjectImmunohistochemistrypt_PT
dc.subjectFormalinpt_PT
dc.titleUsing less than 10% formalin fixed tissue samples in vimentin histochemical detection: possible impact on oncobiological analysis?pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceCoimbrapt_PT
person.familyNameLadeira
person.givenNameCarina
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.orcid0000-0001-5588-0074
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id36463788000
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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