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The characteristics and laboratory findings of SARS-CoV-2 infected patients during the first three COVID-19 waves in Portugal – a retrospective single-center study

2024Journal article Open access
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dc.contributor.authorVon Rekowski, Cristiana
dc.contributor.authorFonseca, Tiago AH
dc.contributor.authorAraújo, Rúben
dc.contributor.authorBrás-Geraldes, Carlos
dc.contributor.authorCalado, Cecília
dc.contributor.authorBento, Luís
dc.contributor.authorPinto, Iola
dc.date.accessioned2024-03-21T18:31:29Z
dc.date.available2024-03-21T18:31:29Z
dc.date.issued2024
dc.description.abstractBackground and Objectives: Given the wide spectrum of clinical and laboratory manifestations of the coronavirus disease 2019 (COVID-19), it is imperative to identify potential contributing factors to patients’ outcomes. However, a limited number of studies have assessed how the different waves affected the progression of the disease, more so in Portugal. Therefore, our main purpose was to study the clinical and laboratory patterns of COVID-19 in an unvaccinated population admitted to the intensive care unit, identifying characteristics associated with death, in each of the first three waves of the pandemic. Materials and Methods: This study included 337 COVID-19 patients admitted to the intensive care unit of a single-center hospital in Lisbon, Portugal, between March 2020 and March 2021. Comparisons were made between three COVID-19 waves, in the second (n = 325) and seventh (n = 216) days after admission, and between discharged and deceased patients. Results: Deceased patients were considerably older (p = 0.021) and needed greater ventilatory assistance (p = 0.023), especially in the first wave. Differences between discharged and deceased patients’ biomarkers were minimal in the first wave, on both analyzed days. In the second wave significant differences emerged in troponins, lactate dehydrogenase, procalcitonin, C-reactive protein, and white blood cell subpopulations, as well as platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios (all p < 0.05). Furthermore, in the third wave, platelets and D-dimers were also significantly different between patients’ groups (all p < 0.05). From the second to the seventh days, troponins and lactate dehydrogenase showed significant decreases, mainly for discharged patients, while platelet counts increased (all p < 0.01). Lymphocytes significantly increased in discharged patients (all p < 0.05), while white blood cells rose in the second (all p < 0.001) and third (all p < 0.05) waves among deceased patients. Conclusions: This study yields insights into COVID-19 patients’ characteristics and mortality-associated biomarkers during Portugal’s first three COVID-19 waves, highlighting the importance of considering wave variations in future research due to potential significant outcome differences.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVon Rekowski CP, Fonseca TAH, Araújo R, Brás-Geraldes C, Calado CRC, Bento L, Pinto I. The characteristics and laboratory findings of SARS-CoV-2 infected patients during the first three COVID-19 waves in Portugal — A retrospective single-center study. Medicina. 2024; 60(1):59. https://doi.org/10.3390/medicina60010059pt_PT
dc.identifier.doihttps://doi.org/10.3390/medicina60010059pt_PT
dc.identifier.issn1648-9144
dc.identifier.urihttp://hdl.handle.net/10400.21/17198
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1648-9144/60/1/59pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectcoronavirus disease 2019pt_PT
dc.subjectintensive care unitpt_PT
dc.subjectmortalitypt_PT
dc.subjectblood biomarkerspt_PT
dc.subjectcoronavirus disease 2019 wavespt_PT
dc.titleThe characteristics and laboratory findings of SARS-CoV-2 infected patients during the first three COVID-19 waves in Portugal – a retrospective single-center studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage21pt_PT
oaire.citation.issue1
oaire.citation.startPage1pt_PT
oaire.citation.titleMedicinapt_PT
oaire.citation.volume60pt_PT
person.familyNameVon Rekowski
person.familyNameHenrique Fonseca
person.familyNameAraújo
person.familyNameBrás-Geraldes
person.familyNameCalado
person.familyNameBento
person.familyNamePinto
person.givenNameCristiana
person.givenNameTiago Alexandre
person.givenNameRúben Alexandre Dinis
person.givenNameCarlos
person.givenNameCecília
person.givenNameLuís
person.givenNameIola
person.identifier1960990
person.identifier130332
person.identifierR-000-ME5
person.identifier.ciencia-id8F1D-1D48-8551
person.identifier.ciencia-id9A18-BFDC-ED95
person.identifier.ciencia-id081A-ABD6-13DD
person.identifier.ciencia-id9418-E320-3177
person.identifier.ciencia-idE711-FA12-4784
person.identifier.ciencia-id5715-2B2D-9ADC
person.identifier.orcid0009-0009-6843-1935
person.identifier.orcid0000-0003-0741-2211
person.identifier.orcid0000-0002-9369-6486
person.identifier.orcid0000-0002-1551-6531
person.identifier.orcid0000-0002-5264-9755
person.identifier.orcid0000-0002-0260-003X
person.identifier.orcid0000-0002-2945-1441
person.identifier.ridA-4358-2019
person.identifier.ridE-2102-2014
person.identifier.ridL-6623-2018
person.identifier.scopus-author-id57197972944
person.identifier.scopus-author-id6603163260
person.identifier.scopus-author-id34969436900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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