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Impact of anabolic steroid consumption on biochemical and hematological parameters in bodybuilders: a systematic review and evidence gap mapping

2024-05Journal article Open access
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dc.contributor.authorTavares, Ana Sofia
dc.contributor.authorVital, Márcia
dc.contributor.authorCunha, Mariana
dc.contributor.authorMaia Matos, Mário
dc.contributor.authorTonin, Fernanda
dc.date.accessioned2024-05-06T09:01:26Z
dc.date.available2024-05-06T09:01:26Z
dc.date.issued2024-05
dc.descriptionThis work was supported by FCT/MCTES (UIDB/05608/2020 and UIDP/05608/2020) – H&TRC.pt_PT
dc.description.abstractThe consumption of anabolic androgenic steroids (AAS) by competitive and non-competitive bodybuilders is relatively common, yet there is diverse and often conflicting evidence on the short- and long-term side-effects of AAS abuse. We aimed at assessing the impact of AAS use (supraphysiological doses/schedule) on adult bodybuilders by means of a broad systematic review and evidence gap mapping (CRD42023401245). Electronic searches in PubMed, Scopus, and Web of Science were performed (Apr-2024). The methodological quality of the included studies was evaluated using the Effective Public Health Practice Project tool. An evidence gap map considering the most reported parameters (e.g., liver, kidney, hematopoietic system) was built. Twenty-two studies (1,023 bodybuilders, of which 662 AAS-users) published between 1987 and 2022, mostly by North America (n = 5 studies; 22.7 %) and West Asia (n = 5; 22.7 %) and mainly designed as cross-sectional case-controls (n = 17; 77.3 %) were synthesized. Testosterone, nandrolone, and stanozolol were the most consumed substances. Altogether, studies reported at least 30 different parameters. Although some parameters, such as urea levels, did not significantly differ between AAS users vs. nonusers (p > 0.05), an increase in both serum alanine and aspartate aminotransferases and a decrease in follicle stimulating and luteinizing hormones (p < 0.05) were reported in AAS users. Evidence is conflicting on the effect of steroids on cholesterol, triglyceride, high density lipoprotein, and low-density lipoprotein levels. Very few studies reported data on hematological parameters. The overall methodological quality of the studies was judged as weak-to-moderate. Further larger and well-designed studies to properly inform about the benefits and risks of AAS on other outcomes are still needed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTavares AS, Vital M, Cunha M, Matos MM, Tonin FS. Impact of anabolic steroid consumption on biochemical and hematological parameters in bodybuilders: a systematic review and evidence gap mapping. Perform Enhanc Health. 2024;12(2):100280.pt_PT
dc.identifier.doi10.1016/j.peh.2024.100280pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17426
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2211266924000124pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBodybuilderpt_PT
dc.subjectSteroidspt_PT
dc.subjectMisusept_PT
dc.subjectEvidence synthesispt_PT
dc.subjectSystematic reviewpt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleImpact of anabolic steroid consumption on biochemical and hematological parameters in bodybuilders: a systematic review and evidence gap mappingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPage100280pt_PT
oaire.citation.titlePerformance Enhancement & Healthpt_PT
oaire.citation.volume12pt_PT
person.familyNameTavares
person.familyNameTonin
person.givenNameAna Sofia
person.givenNameFernanda
person.identifier.ciencia-id9D10-BB39-04DF
person.identifier.ciencia-idD01C-C700-9411
person.identifier.orcid0000-0002-5335-7498
person.identifier.orcid0000-0003-4262-8608
person.identifier.ridO-2050-2017
person.identifier.scopus-author-id56085115800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13fb72b8-212a-4a99-84c3-9038d984d945
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication.latestForDiscovery61ded30e-ecec-4b3e-b953-2293e080ebdd

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