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Ocular repercussions in COVID-19 patients: structural changes of the retina and choroid

2023-12Journal article Embargoed access
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dc.contributor.authorPoças, Ilda Maria
dc.contributor.authorLino, Pedro
dc.contributor.authorSilva, Carina
dc.contributor.authorMendonça, Paula
dc.contributor.authorCunha, João Paulo
dc.contributor.authorBarroqueiro, Olga
dc.contributor.authorCarvalho, Francisca
dc.contributor.authorNicho, Inês
dc.contributor.authorCastelhano, Mariana
dc.contributor.authorCondado, Patrícia
dc.contributor.authorCarmo, Rita
dc.contributor.authorAlmeida, Júlio
dc.contributor.authorPrieto, Isabel
dc.contributor.authorCamacho, Pedro
dc.date.accessioned2023-12-10T13:32:50Z
dc.date.embargo2025-12-10
dc.date.issued2023-12
dc.descriptionThis project was partially supported by an IDI&CA grant [IPL/2020/OCLOVID-19_ESTeSL] by H&TRC- Health & Technology Research Center, ESTeSL- Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa.pt_PT
dc.description.abstractBackground: Neurotropic capabilities of SARS-COVs allow viruses to reach the central nervous system by hematogenous neuronal dissemination. The human retina, as an extension of the Central Nervous System, may have some neurodegenerative and/or vascular modifications related to COVID-19. Objectives: To evaluate choroidal and inner neural layers in participants previously recovered from COVID-19 compared to the control group using optical coherence tomography. Methods: With a cross-sectional approach, the sample (n = 96), consisting of patients who have recovered from COVID-19 (n = 56) and healthy participants control group (n = 40) were ophthalmologically characterized. The neurodegenerative and vascular histological assessment was performed using SD-OCT and the mean thickness was measured in Early Treatment Diabetic Retinopathy Study (ETDRS) subfields. The retinal nerve fiber layer, Ganglion cell layer, and subfoveal choroidal thickness were obtained through semi-automatic measurement. Results: A total of 40 controls (27 women [67.5%]) and 56 COVID-19 participants (34 women [60.8%]) were included in this first report. There were retinal thickness significant differences in nearly all inner ETDRS subfields: nasal 3 mm (p = .025), I3 (p = .049), and temporal 3 mm (p = .009). Also, a decrease in neural layers was found in the nasal 3 mm (p = .049) and temporal 3 mm (p = .029) during ganglion cell layer assessment. The peripapillary retinal nerve fiber layer thickness was thinner in the COVID-19 group in superior temporal (p = .019), nasal (p = .002), inferior temporal (p = .046), and global (p = .014). Concerning the subfoveal choroidal measurement, an increase was observed in the COVID-19 group (p = .002). Conclusion: Participants who had recovered from COVID-19 showed a non-glaucomatous neuropathy trend pattern. We found differences closer to the classic description of the “bow-tie” observed in other neurological as compressive neuropathies at the chiasma location. OCT assessment also showed an increase in choroidal thickness as a result of vascular changes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPoças IM, Lino P, Silva C, Mendonça P, Cunha JC, Camacho P, et al. Ocular repercussions in COVID-19 patients: structural changes of the retina and choroid. Strabismus. 2023;31(4):271-80.pt_PT
dc.identifier.doi10.1080/09273972.2023.2278639pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/16662
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relation.publisherversionhttps://www.tandfonline.com/doi/abs/10.1080/09273972.2023.2278639pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOphthalmologypt_PT
dc.subjectCOVID-19pt_PT
dc.subjectChoroidpt_PT
dc.subjectGanglion cell layerpt_PT
dc.subjectOCTpt_PT
dc.subjectRetina thicknesspt_PT
dc.subjectRetinal nerve fiber layerpt_PT
dc.subjectIPL/2020/OCLOVID-19_ESTeSLpt_PT
dc.titleOcular repercussions in COVID-19 patients: structural changes of the retina and choroidpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage280pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage271pt_PT
oaire.citation.titleStrabismuspt_PT
oaire.citation.volume31pt_PT
person.familyNamePoças
person.familyNameSilva
person.familyNameCamacho
person.givenNameIlda Maria
person.givenNameCarina
person.givenNamePedro
person.identifier.ciencia-id1E1A-86A4-BC50
person.identifier.ciencia-id2411-5936-0820
person.identifier.ciencia-id271F-B4E1-014E
person.identifier.orcid0000-0002-1695-3231
person.identifier.orcid0000-0003-1021-7935
person.identifier.orcid0000-0002-2986-5652
person.identifier.scopus-author-id55258764900
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationced35a9f-848a-49c9-91dc-f60f679f149f
relation.isAuthorOfPublication81a5cd80-1982-43ba-bde5-4c43ae0e5234
relation.isAuthorOfPublicationc41e9c52-157e-4375-8005-b609cfc374e7
relation.isAuthorOfPublication.latestForDiscoveryc41e9c52-157e-4375-8005-b609cfc374e7

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