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Unlocking new avenues: solid-state synthesis of molecularly imprinted polymers

2024-05Journal article Open access
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dc.contributor.authorIacob, Bogdan-Cezar
dc.contributor.authorBodoki, Andreea Elena
dc.contributor.authorCarvalho, Diogo Filipe
dc.contributor.authorPaulino, Antonio Augusto
dc.contributor.authorBarbu-Tudoran, Lucian
dc.contributor.authorBodoki, Ede
dc.date.accessioned2024-06-17T10:58:07Z
dc.date.available2024-06-17T10:58:07Z
dc.date.issued2024-05
dc.description.abstractMolecularly imprinted polymers (MIPs) are established artificial molecular recognition platforms with tailored selectivity towards a target molecule, whose synthesis and functionality are highly influenced by the nature of the solvent employed in their synthesis. Steps towards the "greenification" of molecular imprinting technology (MIT) have already been initiated by the elaboration of green MIT principles; developing MIPs in a solvent-free environment may not only offer an eco-friendly alternative but could also significantly influence the affinity and expected selectivity of the resulting binding sites. In the current study, the first solvent-free mechanochemical synthesis of MIPs via liquid-assisted grinding (LAG) is reported. The successful synthesis of the imprinted polymer was functionally demonstrated by measuring its template rebinding capacity and the selectivity of the molecular recognition process in comparison with the ones obtained by the conventional, non-covalent molecular imprinting process in liquid media. The results demonstrated similar binding capacities towards the template molecule and superior chemoselectivity compared to the solution-based MIP synthesis method. The adoption of green chemistry principles with all their inherent advantages in the synthesis of MIPs may not only be able to alleviate the potential environmental and health concerns associated with their analytical (e.g., selective adsorbents) and biomedical (e.g., drug carriers or reservoirs) applications but might also offer a conceptual change in molecular imprinting technology.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationIacob BC, Bodoki AE, Carvalho DF, Paulino AA, Barbu-Tudoran L, Bodoki E. Unlocking new avenues: solid-state synthesis of molecularly imprinted polymers. Int J Mol Sci. 2024;25(10):5504.pt_PT
dc.identifier.doi10.3390/ijms25105504pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17502
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/25/10/5504pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectLiquid-assisted grindingpt_PT
dc.subjectMechanochemistrypt_PT
dc.subjectMolecular recognitionpt_PT
dc.subjectMolecularly imprinted polymerspt_PT
dc.subjectSolid-state synthesispt_PT
dc.titleUnlocking new avenues: solid-state synthesis of molecularly imprinted polymerspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue10pt_PT
oaire.citation.startPage5504pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume25pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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