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Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust

2017Journal article Open access
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dc.contributor.authorViegas, Susana
dc.contributor.authorAranha Caetano, Liliana
dc.contributor.authorKorkalainen, Merja
dc.contributor.authorFaria, Tiago
dc.contributor.authorPacífico, Cátia
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorGomes, Anita Quintal
dc.contributor.authorViegas, Carla
dc.date.accessioned2017-05-16T10:32:36Z
dc.date.available2017-05-16T10:32:36Z
dc.date.issued2017
dc.description.abstractOrganic dust and related microbial exposures are the main inducers of several respiratory symptoms. Occupational exposure to organic dust is very common and has been reported in diverse settings. In vitro tests using relevant cell cultures can be very useful for characterizing the toxicity of complex mixtures present in the air of occupational environments such as organic dust. In this study, the cell viability and the inflammatory response, as measured by the production of pro-inflammatory cytokines tumor necrosis factor-α (TNFα) and interleukin-1 β (IL-1β), were determined in human macrophages derived from THP-1 monocytic cells. These cells were exposed to air samples from five occupational settings known to possess high levels of contamination of organic dust: poultry and swine feed industries, waste sorting, poultry production and slaughterhouses. Additionally, fungi and particle contamination of those settings was studied to better characterize the organic dust composition. All air samples collected from the assessed workplaces caused both cytotoxic and pro-inflammatory effects. The highest responses were observed in the feed industry, particularly in swine feed production. This study emphasizes the importance of measuring the organic dust/mixture effects in occupational settings and suggests that differences in the organic dust content may result in differences in health effects for exposed workers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationViega S, Caetano LA, Korkalainen L, Faria T, Pacífico C, Carolino E, Gomes AQ, Viegas C. Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust. Toxics. 2017;5(1):8pt_PT
dc.identifier.doi10.3390/toxics5010008pt_PT
dc.identifier.issn2305-6304
dc.identifier.urihttp://hdl.handle.net/10400.21/7011
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttp://www.mdpi.com/2305-6304/5/1/8pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/pt_PT
dc.subjectOrganic dustpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectCytotoxic effectspt_PT
dc.subjectInflammatory effectspt_PT
dc.subjectIn vitropt_PT
dc.titleCytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dustpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage8pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume5pt_PT
person.familyNameViegas
person.familyNameAranha Caetano
person.familyNameCarolino
person.familyNameViegas
person.givenNameSusana
person.givenNameLiliana
person.givenNameElisabete
person.givenNameCarla
person.identifier248817
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id9716-9DAC-532A
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.ciencia-idEE1E-C639-D70F
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0003-1496-2609
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0002-1545-6479
person.identifier.ridI-4053-2012
person.identifier.ridF-1012-2015
person.identifier.ridB-7217-2013
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id25821697000
person.identifier.scopus-author-id55443609700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication6517c656-f913-4f54-8682-77c2856c9e4c
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relation.isAuthorOfPublicationb5fa5da4-50c3-4b88-ae20-1bc63cb485f7
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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