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Dietary synergy of chub mackerel and quinoa in reducing cognitive decline and retinal degeneration in the 5XFAD Alzheimer's mouse model

2026-08Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorGomes-Bispo, Ana
dc.contributor.authorMello-Sampayo, Cristina
dc.contributor.authorCamacho, Pedro
dc.contributor.authorRego, Beatriz
dc.contributor.authorCarvalho, Sandra
dc.contributor.authorLopes, Paula A.
dc.contributor.authorGomes, Romina
dc.contributor.authorOliveira, Susana
dc.contributor.authorLourenço, Maria
dc.contributor.authorPinto, Rui
dc.contributor.authorMotta, Carla
dc.contributor.authorCorreia, Jorge
dc.contributor.authorAfonso, Cláudia
dc.contributor.authorCardoso, Carlos
dc.contributor.authorBandarra, Narcisa M.
dc.contributor.authorPrates, José A. M.
dc.date.accessioned2026-08-27T08:34:44Z
dc.date.available2026-08-27T08:34:44Z
dc.date.issued2026-08
dc.descriptionThis work was supported by FCT (Fundação para a Ciência e a Tecnologia, Lisboa, Portugal) PTDC/SAUNUT/30455/2017 project, the UIDB/00276/2020 grant to CIISA, LA/P/0059/2020 grant to AL4AnimalS, and UIDP/04138/2020 grant to iMed.ULisboa, and FishEUTrust project (grant 101060712, Horizon-CL6-2021-Farm2Fork-01), and GENEMARE_PORTUGAL – Biobanco Azul—Banco Nacional dos Recursos Vivos Marinhos (ref.: MAR-016.9.1-FEAMPA-00008). The authors Ana Gomes-Bispo and Paula A. Lopes also acknowledge FCT for the DL57/2016 Researcher Contracts. The author Romina Gomes wishes to thank FCT for the PhD grant (2021.05300.BD).
dc.description.abstractAlzheimer's disease (AD) is marked by cognitive decline and retinal degeneration. This study aimed to explore the potential of dietary chub mackerel (Scomber colias), rich in docosahexaenoic acid (DHA) and vitamin B12, and quinoa, a source of vitamin B9, to prevent or delay these effects in a 5XFAD mouse model of AD. Thirty-two five-week-old male mice were divided into four groups: control, 10% chub mackerel, 5% quinoa, and 10% chub mackerel plus 5% quinoa, over 28 weeks. After 28 weeks, behavioural tests confirmed that none of the tested diets induced confounding effects related to anxiety-like behaviour or motor impairment. The diet combining chub mackerel and quinoa improved selected memory-associated outcomes and protected retinal integrity (p < 0.05), particularly within the neural layers. This diet also improved the brain n-3/n-6 PUFA ratio, primarily by reducing n-6 PUFA levels rather than by a significant increase in DHA. These benefits likely result from the complementary effects of key nutrients, including DHA and vitamins B9 and B12. The preservation of retinal thickness observed with the combined diet supports the use of retinal layer assessment as a potential non-invasive readout of AD-associated neurodegeneration. These findings indicate that combining chub mackerel and quinoa may help mitigate selected neurodegenerative and retinal alterations in the 5XFAD model, positioning them as promising components of a dietary strategy to support neuroprotection and retinal health during AD-related decline.eng
dc.description.sponsorshipThis work was supported by the FCT (Fundação para a Ciência e a Tecnologia, Lisboa, Portugal) PTDC/SAUNUT/30455/2017 project, the UIDB/00276/2020 grant to CIISA, the LA/P/0059/2020 grant to AL4AnimalS, and the UIDP/04138/2020 grant to iMed.ULisboa, and the FishEUTrust project (grant 101060712, Horizon-CL6-2021-Farm2Fork-01), and GENEMARE_PORTUGAL – Biobanco Azul—Banco Nacional dos Recursos Vivos Marinhos (ref.: MAR-016.9.1-FEAMPA-00008). The authors Ana Gomes-Bispo and Paula A. Lopes also acknowledge FCT for the DL57/2016 Researcher Contracts. The author Romina Gomes wishes to thank FCT for the PhD grant (2021.05300.BD).
dc.identifier.citationGomes-Bispo A, Mello-Sampayo C, Camacho P, Rego B, Carvalho S, Lopes PA, et al. Dietary synergy of chub mackerel and quinoa in reducing cognitive decline and retinal degeneration in the 5XFAD Alzheimer’s mouse model. Heliyon. 2026;12(13):e45219.
dc.identifier.doi10.1016/j.heliyon.2026.e45219
dc.identifier.issn2405-8440
dc.identifier.urihttp://hdl.handle.net/10400.21/23021
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier BV
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S2405844026007322
dc.relation.ispartofHeliyon
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectChub mackerel
dc.subjectQuinoa
dc.subjectAlzheimer's disease
dc.subject5XFAD mouse model
dc.subjectCognitive decline
dc.subjectRetinal health
dc.titleDietary synergy of chub mackerel and quinoa in reducing cognitive decline and retinal degeneration in the 5XFAD Alzheimer's mouse modeleng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue13
oaire.citation.startPagee45219
oaire.citation.titleHeliyon
oaire.citation.volume12
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCamacho
person.givenNamePedro
person.identifier.ciencia-id271F-B4E1-014E
person.identifier.orcid0000-0002-2986-5652
relation.isAuthorOfPublicationc41e9c52-157e-4375-8005-b609cfc374e7
relation.isAuthorOfPublication.latestForDiscoveryc41e9c52-157e-4375-8005-b609cfc374e7

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