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Advisor(s)
Abstract(s)
Introdução – O cálculo do maximum standardized uptake value (SUVmax) em tomografia por emissão de positrões (PET) com [68Ga]Ga-DOTA-TATE permite quantificar a densidade de recetores da somatostatina, sobreexpressos pelos tumores neuroendócrinos (TNE). A sua análise em função do padrão normal e patológico complementa a avaliação visual dos exames, mas na literatura existe controvérsia quanto a esta diferenciação. O objetivo deste trabalho foi avaliar os valores de SUVmax fisiológico (SUVmax_f) e patológico (SUVmax_p) em função da captação de [68Ga]Ga-DOTA-TATE em diferentes órgãos. Materiais e Métodos – Esta revisão sistemática foi conduzida de acordo com as orientações da checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A pesquisa incluiu os termos relacionados com SUVmax, PET/CT, [68Ga]Ga-DOTA-TATE e NET, na PubMed, Scopus e Web of Science. Os estudos selecionados foram referentes a TNE avaliados por PET/CT com [68Ga]Ga-DOTA-TATE, com discriminação da localização, dos valores de SUVmax e do grau histológico das lesões. Utilizaram-se técnicas de estatística descritiva para análise dos dados. Resultados/Discussão – Dos 20 artigos selecionados obtiveram-se valores de SUVmax_f e SUVmax_p de vários órgãos. Os gânglios linfáticos, a hipófise, o pâncreas e o fígado foram os órgãos que apresentaram a maior diferença entre os valores de SUVmax_f e SUVmax_p, respetivamente: (1,1) e (6,0; 26,3), (2,0; 11,0) e (24,2), (3,5; 9,2) e (20,4; 87,6), e (6,5; 10,1) e (14,5; 40,0). O reduzido número de amostras e a inclusão de lesões de diferentes graus histológicos parece ter influenciado esta segmentação. Conclusão – O valor médio de SUVmax_f e SUVmax_p do [68Ga]Ga-DOTA-TATE é variável nos diferentes órgãos. A avaliação deste parâmetro permite estabelecer a distinção entre captação fisiológica e patológica, particularmente em órgãos como gânglios linfáticos, pâncreas, hipófise e trato gastrointestinal (GI).
ABSTRACT - Introduction – The maximum standardized uptake value (SUVmax) determination in Positron Emission Tomography (PET) with [68Ga] Ga-DOTA-TATE, allows the quantification of the density of somatostatin receptors, overexpressed by Neuroendocrine Tumors (NET). Related to the physiological and pathological pattern, the SUVmax analysis complements the visual assessment, yet this differentiation is controversial in the literature. The aim of this study was to evaluate the values of physiological and pathological SUVmax of [68Ga] Ga-DOTA-TATE in different organs. Methods – This systematic review was carried out according to the guidelines of the checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA). Relevant articles were searched in PubMed, Scopus, and Web of Science, including the terms: SUVmax, PET/CT, [68Ga] Ga-DOTA-TATE, and NET. Articles, where NET was studied by [68Ga] Ga-DOTA-TATE PET/CT, using the SUVmax determination and presenting the histological grade of the lesions, were included. Descriptive statistics were used for data analysis. Results/Discussion – Physiological and pathological SUVmax values were collected from 20 articles included in the study. The lymph nodes, pituitary, pancreas, and liver were the organs that presented the greatest difference between physiological and pathological SUVmax, respectively: (1.1) and (6.0; 26.3), (2.0; 11.0) and (24.2), (3.5; 9.2) and (20.4; 87.6), and (6.5; 10.1) and (14.5; 40.0). The sample size and the inclusion of lesions with different grades may have influenced this segmentation. Conclusion – The average physiological and pathological SUVmax of [68Ga] Ga-DOTA-TATE is variable in different organs. Accordingly, by using this parameter it was possible to differentiate physiological and pathological uptake in organs such as lymph nodes, pancreas, pituitary, and GI tract.
ABSTRACT - Introduction – The maximum standardized uptake value (SUVmax) determination in Positron Emission Tomography (PET) with [68Ga] Ga-DOTA-TATE, allows the quantification of the density of somatostatin receptors, overexpressed by Neuroendocrine Tumors (NET). Related to the physiological and pathological pattern, the SUVmax analysis complements the visual assessment, yet this differentiation is controversial in the literature. The aim of this study was to evaluate the values of physiological and pathological SUVmax of [68Ga] Ga-DOTA-TATE in different organs. Methods – This systematic review was carried out according to the guidelines of the checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA). Relevant articles were searched in PubMed, Scopus, and Web of Science, including the terms: SUVmax, PET/CT, [68Ga] Ga-DOTA-TATE, and NET. Articles, where NET was studied by [68Ga] Ga-DOTA-TATE PET/CT, using the SUVmax determination and presenting the histological grade of the lesions, were included. Descriptive statistics were used for data analysis. Results/Discussion – Physiological and pathological SUVmax values were collected from 20 articles included in the study. The lymph nodes, pituitary, pancreas, and liver were the organs that presented the greatest difference between physiological and pathological SUVmax, respectively: (1.1) and (6.0; 26.3), (2.0; 11.0) and (24.2), (3.5; 9.2) and (20.4; 87.6), and (6.5; 10.1) and (14.5; 40.0). The sample size and the inclusion of lesions with different grades may have influenced this segmentation. Conclusion – The average physiological and pathological SUVmax of [68Ga] Ga-DOTA-TATE is variable in different organs. Accordingly, by using this parameter it was possible to differentiate physiological and pathological uptake in organs such as lymph nodes, pancreas, pituitary, and GI tract.
Description
Keywords
Medicina nuclear SUVmax [68Ga]Ga-DOTA-TATE PET-CT NET Tumor neuroendócrino Nuclear medicine Neuroendocrine tumor
Citation
Maricato C, Aguiar I, Valente S, Figueiredo S. Avaliação do SUVmax na captação do [68Ga]Ga-DOTA-TATE PET/CT em doentes com tumores neuroendócrinos: revisão de literatura. Saúde & Tecnologia. 2022;(27):30-43.
Publisher
Instituto Politécnico de Lisboa, Escola Superior de Tecnologia da Saúde de Lisboa