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Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review

2022-02Journal article Open access
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dc.contributor.authorViegas, Carla
dc.contributor.authorPena, Pedro
dc.contributor.authorGomes, Bianca
dc.contributor.authorDias, Marta
dc.contributor.authorCaetano, Liliana Aranha
dc.contributor.authorViegas, Susana
dc.date.accessioned2022-02-09T16:04:50Z
dc.date.available2022-02-09T16:04:50Z
dc.date.issued2022-02
dc.descriptionProject “Occupational exposure of ambulance drivers to bioburden” (IPL/2020/BIO-AmbuDrivers_ESTeSL).pt_PT
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractIn some occupational environments, risk characterization is challenging or impossible to achieve due to the presence of multiple pollutants and contaminants. Thus, in vitro testing using the most relevant cell lines will provide information concerning health effects due to the co-exposure to multiple stressors. The aim of this review article is to identify studies where the cytotoxicity assessment was performed in environmental samples, as well as to describe the main outputs and challenges regarding risk characterization and management. This study is based on a study of the available information/data on cytotoxicity assessment performed on environmental samples following the PRISMA methodology. Different cell lines were used depending on the environment assessed and exposure routes implicated. The A549 alveolar epithelial cell line was applied in four studies for occupational exposure in the waste sorting industry and for outdoor environments; lymphocytes were used in two studies for occupational and outdoor environments; swine kidney cells were used in three studies performed in the waste industry and hepatocellular/Hep G2 in one study in the waste industry. Cytotoxicity assessments in environmental samples should have a more prominent role due to their contribution to identifying and better understanding the associations between co-exposure to environmental contaminants and adverse human health effects as a prioritization for risk management.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationViegas C, Pena P, Gomes B, Dias M, Caetano LA, Viegas S. Are in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic review. Toxics. 2022;10(2):72.pt_PT
dc.identifier.doi10.3390/toxics10020072pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14277
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationProject “Occupational exposure of ambulance drivers to bioburden” (IPL/2020/BIO-AmbuDrivers_ESTeSL)pt_PT
dc.relationProject IPL/2020/BIO-AmbuDrivers_ESTeSLpt_PT
dc.relationFCT_UIDB/05608/2020pt_PT
dc.relationFCT_UIDP/05608/2020pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2305-6304/10/2/72pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectMultiple contaminantspt_PT
dc.subjectEnvironmental samplespt_PT
dc.subjectIn vitro studiespt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectRisk managementpt_PT
dc.subjectProject Occupational exposure of ambulance drivers to bioburdenpt_PT
dc.subjectIPL/2020/BIO-AmbuDrivers_ESTeSLpt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleAre in vitro cytotoxicity assessments of environmental samples useful for characterizing the risk of exposure to multiple contaminants at the workplace? A systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPage72pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume10pt_PT
person.familyNameViegas
person.familyNamePena
person.familyNameGomes
person.familyNameDias
person.familyNameAranha Caetano
person.familyNameViegas
person.givenNameCarla
person.givenNamePedro
person.givenNameBianca
person.givenNameMarta
person.givenNameLiliana
person.givenNameSusana
person.identifier2041141
person.identifier2371423
person.identifier248817
person.identifier.ciencia-idEE1E-C639-D70F
person.identifier.ciencia-idD71B-656F-BB9D
person.identifier.ciencia-idAD1E-B4CE-389D
person.identifier.ciencia-id4E1B-16BB-80C7
person.identifier.ciencia-id9716-9DAC-532A
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0002-1545-6479
person.identifier.orcid0000-0002-2188-9318
person.identifier.orcid0000-0002-6264-6072
person.identifier.orcid0000-0002-2704-6995
person.identifier.orcid0000-0003-1496-2609
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridB-7217-2013
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id55443609700
person.identifier.scopus-author-id57222077827
person.identifier.scopus-author-id35270591500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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