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Malaria in children and G6PD deficiency in an endemic area for malaria in Bengo province, Angola

2018-04Conference object Open access
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dc.contributor.authorBrito, Miguel
dc.contributor.authorTchonhi, Chissengo
dc.date.accessioned2019-01-17T16:31:43Z
dc.date.available2019-01-17T16:31:43Z
dc.date.issued2018-04
dc.description.abstractGlucose 6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway, important in the protection of cells against oxidative stress. The G6PD deficiency is the most common enzymopathy X linked worldwide. The majority of the G6PD deficient do not manifest any symptoms, however, acute hemolytic anemia may be trigger by several agents, such as primaquine. Current WHO guidelines state that in elimination areas a single 0.25 mg base/kg primaquine dose should be given, as a gametocytocide, to all patients with parasitological-confirmed P. falciparum malaria on the first day of treatment in addition to an ACT. In face of this recommendation, endemic malaria countries should be informed of the prevalence of G6PD deficiency, in order to make safe and appropriate decisions regarding the use of potentially unsafe drugs for G6PD deficient individuals. Objectives: The aim of this study is to determine the prevalence of G6PD deficiency in a holoendemic region in Africa for P falciparum, evaluating the genotype and the phenotype of the enzyme.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBrito M, Tchonhi C. Malaria in children and G6PD deficiency in an endemic area for malaria in Bengo province, Angola. In: ESH-GR-EX – 2nd International Symposium on Red Blood Cells: genesis and pathophysiology, Marriott Rive Gauche, Paris (France), April 18-20, 2018.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/9337
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttp://www.esh.org/conference/esh-gr-ex-symposium-on-red-blood-cells-genesis-and-pathophysiology/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMalariapt_PT
dc.subjectG6PD deficiencypt_PT
dc.subjectChildrenpt_PT
dc.subjectAngolapt_PT
dc.subjectProvíncia do Bengopt_PT
dc.titleMalaria in children and G6PD deficiency in an endemic area for malaria in Bengo province, Angolapt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceParispt_PT
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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