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High incidence of early thalamic lesions in the Continuous Spike-Wave related with slow Sleep (CSWS)

2023-01Journal article Open access
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dc.contributor.authorCarvalho, Daniel
dc.contributor.authorMendonça, Carla
dc.contributor.authorCarvalho, João
dc.contributor.authorMartins, Ana
dc.contributor.authorLeal, Alberto
dc.date.accessioned2022-12-28T12:53:05Z
dc.date.available2024-12-28T01:30:24Z
dc.date.issued2023-01
dc.description.abstractObjective: Continuous Spike-Wave during slow Sleep (CSWS) syndrome associates a clinically important neurocognitive regression with strong activation of non-REM sleep spikes. Its mechanisms remain unknown, but a contribution of rare perinatal thalamic injuries has been highlighted. We determine the incidence of such lesions in a cohort of CSWS patients. Methods: N = 65 patients with CSWS and a control group (N = 51) were studied. Spikes were quantified in long-term ambulatory EEGs, brain Magnetic Resonance Imaging (MRI) structural lesions were assessed and thalamic volumetry was performed. A neurocognitive scale was used to assess dysfunction. Results: The most common etiologies in the control patients were not represented in the CSWS group. Structural lesions were detected in a minority of CSWS patients (25/53) but included a thalamic injury in the large majority (24/25). This ratio was 4/40 in controls. Lesions belonged to one of five types: 1. Circumscribed to the thalamus (N = 11); 2. Extending beyond the thalamus (N = 3); 3. Hypothalamic-Hamartomas (N = 4); 4. Periventricular-Leukomalacia (N = 4); 5. Hypoplasia-Polymicrogyria (N = 1). Most lesions were lateralized to one hemisphere, which in all cases corresponded to the lateralization of the CSWS. Significance: Thalamic lesions are present in most CSWS patients with abnormal MRIs, supporting an important role in its genesis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCarvalho D, Mendonça C, Carvalho J, Martins A, Leal A. High incidence of early thalamic lesions in the Continuous Spike-Wave related with slow Sleep (CSWS). Epilepsy Behav. 2023;138:109031.pt_PT
dc.identifier.doi10.1016/j.yebeh.2022.109031pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15209
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1525505022004802pt_PT
dc.subjectContinuous Spike-Wave related with slow Sleeppt_PT
dc.subjectCSWSpt_PT
dc.subjectESESpt_PT
dc.subjectEpileptic encephalopathypt_PT
dc.subjectPediatric epilepsypt_PT
dc.subjectThalamuspt_PT
dc.titleHigh incidence of early thalamic lesions in the Continuous Spike-Wave related with slow Sleep (CSWS)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage109031pt_PT
oaire.citation.titleEpilepsy & Behaviorpt_PT
oaire.citation.volume138pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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