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Impact of harm minimization interventions on reducing blood-borne infection transmission and some injecting behaviors among people who inject drugs: an overview and evidence gap mapping

2024-02Journal article Open access
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dc.contributor.authorTonin, Fernanda
dc.contributor.authorAlves da Costa, Filipa
dc.contributor.authorFernandez-Llimos, Fernando
dc.date.accessioned2024-02-05T10:51:42Z
dc.date.available2024-02-05T10:51:42Z
dc.date.issued2024-02
dc.description.abstractBackground: This study aimed to synthetize the evidence on the effectiveness of harm minimization interventions in reducing blood-borne infection transmission and injecting behaviors among people who inject drugs (PWID) through a comprehensive overview of systematic reviews and evidence gap mapping. Methods: A systematic review was conducted with searches in PubMed and Scopus to identify systematic reviews assessing the impact of interventions aimed at reducing the harms associated with injectable drug use. The overall characteristics of the studies were extracted and their methodological quality was assessed using AMSTAR-2. An evidence gap map was constructed, highlighting the most frequently reported outcomes by intervention (CRD42023387713). Results: Thirty-three systematic reviews were included. Of these, 14 (42.2%) assessed the impact of needle/syringe exchange programs (NSEP) and 11 (33.3%) examined opioid agonist therapy (OAT). These interventions are likely to be associated with reductions of HIV/HCV incidence (10-40% risk reduction for NSEP; 50-60% for OAT) and sharing injecting paraphernalia (50% for NSEP, 25-85% for OAT), particularly when combined (moderate evidence). Behavioral/educational interventions were assessed in 12 reviews (36.4%) with most authors in favor/partially in favor of the use of these approaches (moderate evidence). Take-home naloxone programs and supervised injection facilities were each assessed in two studies (6.1%), which reported inconclusive results (limited/inconsistent evidence). Most authors reported high levels of heterogeneity and risk of bias. Other interventions and outcomes were inadequately reported. Most systematic reviews presented low or critically low quality. Conclusion: The evidence is sufficient to support the effectiveness of OAT, NSEP, and their combination in reducing blood-borne infection transmission and certain injecting behaviors among PWID. However, evidence of other harm minimization interventions in different settings and for some outcomes remains insufficient.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTonin FS, Alves da Costa F, Fernandez-Llimos F. Impact of harm minimization interventions on reducing blood-borne infection transmission and some injecting behaviors among people who inject drugs: an overview and evidence gap mapping. Addict Sci Clin Pract. 2024;19(1):9.pt_PT
dc.identifier.doi10.1186/s13722-024-00439-9pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17047
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://ascpjournal.biomedcentral.com/articles/10.1186/s13722-024-00439-9pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBlood-borne infectionspt_PT
dc.subjectEvidence gapspt_PT
dc.subjectHarm reductionpt_PT
dc.subjectInjectable drug usept_PT
dc.subjectSystematic reviewpt_PT
dc.titleImpact of harm minimization interventions on reducing blood-borne infection transmission and some injecting behaviors among people who inject drugs: an overview and evidence gap mappingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage9pt_PT
oaire.citation.titleAddiction Science & Clinical Practicept_PT
oaire.citation.volume19pt_PT
person.familyNameTonin
person.givenNameFernanda
person.identifier.ciencia-idD01C-C700-9411
person.identifier.orcid0000-0003-4262-8608
person.identifier.ridO-2050-2017
person.identifier.scopus-author-id56085115800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication.latestForDiscovery61ded30e-ecec-4b3e-b953-2293e080ebdd

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