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Geographical variation in lung function: results from the multicentric cross-sectional BOLD study

2025Journal article Open access
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dc.contributor.authorBurney, Peter G.
dc.contributor.authorPotts, James
dc.contributor.authorKnox-Brown, Ben
dc.contributor.authorErhabor, Gregory
dc.contributor.authorHacene Cherkaski, Hamid
dc.contributor.authorMortimer, Kevin
dc.contributor.authorAnand, Mahesh Padukudru
dc.contributor.authorMannino, David M.
dc.contributor.authorCardoso, Joao
dc.contributor.authorAhmed, Rana
dc.contributor.authorElsony, Asma
dc.contributor.authorBarbara, Cristina
dc.contributor.authorNielsen, Rune
dc.contributor.authorBateman, Eric
dc.contributor.authorParaguas, Stefanni Nonna
dc.contributor.authorCher Loh, Li
dc.contributor.authorRashid, Abdul
dc.contributor.authorWouters, Emiel F.
dc.contributor.authorFranssen, Frits M.
dc.contributor.authorDias, Hermínia Brites
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorGhobain, Mohammed A.
dc.contributor.authorBiaze, Mohammed El
dc.contributor.authorAgarwal, Dhiraj
dc.contributor.authorJuvekar, Sanjay
dc.contributor.authorRodrigues, Fatima
dc.contributor.authorObaseki, Daniel O.
dc.contributor.authorKoul, Parvaiz A.
dc.contributor.authorHarrabi, Imed
dc.contributor.authorNafees, Asaad A
dc.contributor.authorSeemungal, Terence
dc.contributor.authorJanson, Christer
dc.contributor.authorVollmer, William M
dc.contributor.authorAmaral, Andre F.
dc.contributor.authorBuist, A Sonia
dc.date.accessioned2024-12-10T14:57:53Z
dc.date.available2024-12-10T14:57:53Z
dc.date.issued2025
dc.description.abstractSpirometry is used to determine what is "unusual" lung function compared with what is "usual" for healthy non-smokers. This study aimed to investigate regional variation in the forced vital capacity (FVC) and in the forced expiratory volume in one second to FVC ratio (FEV1/FVC) using cross-sectional data from all 41 sites of the multinational Burden of Obstructive Lung Disease study. Participants (5,368 men; 9,649 women), aged ≥40 years, had performed spirometry, had never smoked and reported no respiratory symptoms or diagnoses. To identify regions with similar FVC, we conducted a principal component analysis (PCA) on FVC with age, age2 and height2, separately for men and women. We regressed FVC against age, age2 and height2, and FEV1/FVC against age and height2, for each sex and site, stratified by region. Mean age was 54 years (both sexes), and mean height was 1.69 m (men) and 1.61 m (women). The PCA suggested four regions: 1) Europe and richer countries; 2) the Near East; 3) Africa; and 4) the Far East. For the FVC, there was little variation in the coefficients for age, or age2, but considerable variation in the constant (men: 2.97 L in the Far East to 4.08 L in Europe; women: 2.44 L in the Far East to 3.24 L in Europe) and the coefficient for height2. Regional differences in the constant and coefficients for FEV1/FVC were minimal (<1%). The relation of FVC with age, sex and height varies across and within regions. The same is not true for the FEV1/FVC ratio.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBurney PG, Potts J, Knox-Brown B, Erhabor G, Hacene Cherkaski H, Dias HB, et al. Geographical variation in lung function: results from the multicentric cross-sectional BOLD study. Pulmonology. 2025;31(1):2430491.pt_PT
dc.identifier.doi10.1080/25310429.2024.2430491pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/18001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/25310429.2024.2430491pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPneumologypt_PT
dc.subjectAirflow obstructionpt_PT
dc.subjectForced expiratory volumept_PT
dc.subjectForced vital capacitypt_PT
dc.subjectGlobal healthpt_PT
dc.subjectCross-sectional studypt_PT
dc.titleGeographical variation in lung function: results from the multicentric cross-sectional BOLD studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage2430491pt_PT
oaire.citation.titlePulmonologypt_PT
oaire.citation.volume31pt_PT
person.familyNameDias
person.givenNameMaria Hermínia Monteiro Brites
person.identifier.ciencia-idE211-FB1B-04E3
person.identifier.orcid0000-0003-1257-8734
person.identifier.ridAFL-8310-2022
person.identifier.scopus-author-id55671930200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb7b7e7d9-83b2-4d63-9176-4ed73cf6b939
relation.isAuthorOfPublication.latestForDiscoveryb7b7e7d9-83b2-4d63-9176-4ed73cf6b939

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