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Thickness profile of the ganglion cell complex and choroid in patients with persistent diabetic macular edema

2025-11Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorCondelipes, Ana
dc.contributor.authorCorreia, Daniela
dc.contributor.authorFernandes, Inês
dc.contributor.authorSilva, Tiago
dc.contributor.authorCorreia, Eduardo
dc.contributor.authorPereira, Bruno
dc.contributor.authorCamacho, Pedro
dc.date.accessioned2025-12-16T10:49:54Z
dc.date.available2025-12-16T10:49:54Z
dc.date.issued2025-11
dc.descriptionThis project was partially supported by an IDI&CA grant IPL/2021/DiffMeDiME_ESTeSL, by H&TRC- Health & Technology Research Center, ESTeSL- Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, FCT/MCTES national support through the UIDP/05608/2020, UIDB/05608/2020, and by Retina Institute of Lisbon (IRL).
dc.description.abstractPurpose: Approximately 40% of patients with diabetic macular edema (DME) do not respond optimally to first-line treatment with intravitreal injections of anti-vascular endothelial growth factor (VEGF). Evidence suggests that additional vascular and neurodegenerative mechanisms may be involved. This study aimed to characterise the thickness of the Ganglion Cell Complex (GCC) and investigate the Choroidal Vascularity Index (CVI) in patients with different patterns of therapeutic response to AVEGF DME. Methods: This cross-sectional study included 27 diabetic patients divided into three groups based on their response to AVEGF therapy: a control group, a responder DME group, and a persistent DME group. The study's approach to vascular and neurodegenerative imaging biomarkers involved three steps: (1) Automatic quantification of GCC thickness, with manual correction when necessary; (2) Semi-automatic measurement of choroidal thickness; and (3) Analysis of choroidal area and choroidal luminal area using ImageJ software to calculate the CVI. Results: In the overall characterization of the sample, a significant difference was observed only in the Best Corrected Visual Acuity (BCVA). There was a significant difference in Average Retinal Thickness (1 mm, 3 mm, and 6 mm) between the 3 groups and in GCC thickness at 1 mm. BCVA was negatively correlated with mean retinal thickness, while CVI showed a potential positive correlation with BCVA. Conclusions: While demographic and general clinical characteristics showed minimal differences across the groups, important differences in GCC and choroidal characteristics were observed. GCC (1 mm) may be interesting to explore in predicting visual outcomes after treatment, and CVI may impact visual gain.eng
dc.identifier.citationCondelipes A, Correia D, Fernandes I, Silva T, Pereira B, Camacho P, et al. Thickness profile of the ganglion cell complex and choroid in patients with persistent diabetic macular edema. Comput Biol Med. 2025;198(Pt A):111192.
dc.identifier.doi10.1016/j.compbiomed.2025.111192
dc.identifier.issn0010-4825
dc.identifier.urihttp://hdl.handle.net/10400.21/22325
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier BV
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0010482525015458
dc.relation.ispartofComputers in Biology and Medicine
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectOphthalmology
dc.subjectOrthoptics
dc.subjectChoroid
dc.subjectDiabetes mellitus
dc.subjectDiabetic macular edema
dc.subjectDiabetic retinopathy
dc.subjectGanglion cell complex
dc.subjectSD-OCT
dc.subjectFCT_UIDB/05608/2020
dc.subjectFCT_UIDP/05608/2020
dc.subjectIPL/2021/DiffMeDiME_ESTeSL
dc.titleThickness profile of the ganglion cell complex and choroid in patients with persistent diabetic macular edemaeng
dc.typejournal article
dcterms.referenceshttps://doi.org/10.1016/j.compbiomed.2025.111192
dspace.entity.typePublication
oaire.citation.issuePt A
oaire.citation.startPage111192
oaire.citation.titleComputers in Biology and Medicine
oaire.citation.volume198
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNamePereira
person.familyNameCamacho
person.givenNameBruno
person.givenNamePedro
person.identifier.ciencia-id271F-B4E1-014E
person.identifier.orcid0000-0001-9269-8335
person.identifier.orcid0000-0002-2986-5652
relation.isAuthorOfPublication2a6ea9cf-68c0-405c-a961-26a3eeb59136
relation.isAuthorOfPublicationc41e9c52-157e-4375-8005-b609cfc374e7
relation.isAuthorOfPublication.latestForDiscoveryc41e9c52-157e-4375-8005-b609cfc374e7

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