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Advisor(s)
Abstract(s)
Solution enthalpies of paracetamol, ΔsolH, in choline chloride–ethylene glycol–water mixtures were evaluated at 298.15 K. Solvatochromic UV–vis shifts of fve diferent probes (4-nitroaniline, 4-nitroanisole, 4-nitrophenol, N,N-dimethyl-4-nitroani line and 2,6-diphenyl-4-(2,4,6-triphenylpyridinium-1-yl)phenolate) were also assessed for the same mixtures at the same temperature in order to compute the corresponding Kamlet–Taft parameters, α, β, and π*. Quantitative structure–property relationships (QSPR) between ΔsolH and the solvatochromic parameters were established to investigate the solution pro cesses under consideration. Due to the small variability in the solvent parameters, a further set of eight pure solvents were considered. The behavior of paracetamol in eutectic mixtures is shown to be not signifcantly diferent from its behaviour in the pure solvents. The solvents’ basicity measured by β, is the most relevant factor modeling the solution process of this solute in the total set of solvents.
Description
Keywords
ternary mixture choline chloride ethylene glycol water Kamlet–Taft parameters solution enthalpies
Citation
Lopes A, Nunes N, Leitão RE, Martins F. Insights into the thermochemistry of paracetamol in ternary mixtures of eutectic solvents. Journal of Thermal Analysis and Calorimetry. 2024; 149(17), 9439–9449. https://doi.org/10.1007/s10973-024-13383-2
Publisher
Springer