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Dosimetric effect of tissue heterogeneity for 125I prostate implants

2014-04Journal article Restricted access
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dc.contributor.authorOliveira, Susana Maria
dc.contributor.authorTeixeira, Nuno
dc.contributor.authorFernandes, Lisete
dc.contributor.authorTeles, Pedro
dc.contributor.authorVaz, Pedro
dc.date.accessioned2015-03-16T17:48:50Z
dc.date.available2015-03-16T17:48:50Z
dc.date.issued2014-04
dc.description.abstractAim - To use Monte Carlo (MC) together with voxel phantoms to analyze the tissue heterogeneity effect in the dose distributions and equivalent uniform dose (EUD) for (125)I prostate implants. Background - Dose distribution calculations in low dose-rate brachytherapy are based on the dose deposition around a single source in a water phantom. This formalism does not take into account tissue heterogeneities, interseed attenuation, or finite patient dimensions effects. Tissue composition is especially important due to the photoelectric effect. Materials and Methods - The computed tomographies (CT) of two patients with prostate cancer were used to create voxel phantoms for the MC simulations. An elemental composition and density were assigned to each structure. Densities of the prostate, vesicles, rectum and bladder were determined through the CT electronic densities of 100 patients. The same simulations were performed considering the same phantom as pure water. Results were compared via dose-volume histograms and EUD for the prostate and rectum. Results - The mean absorbed doses presented deviations of 3.3-4.0% for the prostate and of 2.3-4.9% for the rectum, when comparing calculations in water with calculations in the heterogeneous phantom. In the calculations in water, the prostate D 90 was overestimated by 2.8-3.9% and the rectum D 0.1cc resulted in dose differences of 6-8%. The EUD resulted in an overestimation of 3.5-3.7% for the prostate and of 7.7-8.3% for the rectum. Conclusions - The deposited dose was consistently overestimated for the simulation in water. In order to increase the accuracy in the determination of dose distributions, especially around the rectum, the introduction of the model-based algorithms is recommended.por
dc.identifier.citationOliveira SM, Teixeira NJ, Fernandes L, Teles P, Vaz P. Dosimetric effect of tissue heterogeneity for (125)I prostate implants. Rep Pract Oncol Radiother. 2014;19(6):392-8.por
dc.identifier.doi10.1016/j.rpor.2014.03.004
dc.identifier.urihttp://hdl.handle.net/10400.21/4379
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1507136714000376#por
dc.subjectBrachytherapypor
dc.subjectProstate cancerpor
dc.subjectMonte Carlopor
dc.subjectTissue heterogeneitypor
dc.subjectModel-based calculation algorithmspor
dc.subjectComputerized tomographypor
dc.subjectDose–volume histogrampor
dc.subjectExternal beam radiotherapypor
dc.subjectEquivalent uniform dosepor
dc.subjectNormal tissue complication probabilitypor
dc.subjectTumor control probabilitypor
dc.subjectDifferential dose–volume histogrampor
dc.titleDosimetric effect of tissue heterogeneity for 125I prostate implantspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage398por
oaire.citation.startPage392por
oaire.citation.titleReports of Practical Oncology & Radiotherapypor
oaire.citation.volume19por
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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