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Foveal avascular zone area measurement in diabetic patients: superficial, deep or combined retinal vascular complex?

2025-01Journal article Open access
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dc.contributor.authorPereira, Bruno
dc.contributor.authorFaria, Ross
dc.contributor.authorDomingues, Cátia
dc.contributor.authorBarros, Ana
dc.contributor.authorVarandas, Teresa
dc.contributor.authorHenriques, José
dc.contributor.authorNascimento, João
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorCamacho, Pedro
dc.date.accessioned2024-09-18T09:59:30Z
dc.date.available2024-09-18T09:59:30Z
dc.date.issued2025-01
dc.descriptionThis project was partially supported by an IDI&CA Grant, IPL/2021/DiffMeDiME_ESTeSL.pt_PT
dc.description.abstractPurpose: To compare differences in the foveal avascular zone (FAZ) area, measured in the Superficial Vascular Complex (SVC), Deep Vascular Complex (DVC), and a combined analysis of both (SDVC), using two Spectral Domain OCT angiography (OCT-A) protocols, High Speed (HS) and High Resolution (HR). Methods: A total of 26 eyes of diabetic patients, with and without macular oedema, were examined with two different fovea-centered OCT-A volume scans. The two protocols were HS and HR volume scans, and the foveal avascular zone was manually measured in the SVC, DVC, and SDVC slabs by two masked investigators. Inter and intraoperator variability was analysed using Intraclass Correlation Coefficient (ICC) and differences were compared between the HR and HS acquisitions throughout the different vascular slabs. Results: Intraoperator variability was low in all slabs (ICC > 0.9) and interoperator variability was lower for HR (ICC 0.835-0.911) compared to HS (ICC between 0.604 and 0.865). Comparing HS and HR measurements for the same slab, the correlation was only moderate in SVC and DVC (ICC was 0.640 and 0.568 respectively) but was good in the SDVC (ICC = 0.823). FAZ area measurement in SDVC also showed the smallest bias (mean difference 0.009 mm2) and the narrowest limits of agreement (-0.175 to 0.193 mm2). Conclusions: Even in cases of diabetic macular oedema, when measuring the FAZ area, the reproducibility was better between HS and HR protocols when using the SDVC slab, compared to the SVC or DVC slabs alone. Further studies should evaluate the use of the combined SDVC slab for the FAZ assessment, compared to the SVC and DVC slabs alone, in detecting and progressing different retinal diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPereira B, Faria R, Domingues C, Barros A, Carolino E, Camacho P, et al. Foveal avascular zone area measurement in diabetic patients: superficial, deep or combined retinal vascular complex? Microvasc Res. 2025;157:104743.pt_PT
dc.identifier.doi10.1016/j.mvr.2024.104743pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17705
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIPL/2021/DiffMeDiME_ESTeSLpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S002628622400092Xpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOphthalmologypt_PT
dc.subjectDeep vascular complexpt_PT
dc.subjectDiabetic retinopathypt_PT
dc.subjectFoveal avascular zone areapt_PT
dc.subjectMacular edema, repeatabilitypt_PT
dc.subjectOptical coherence tomography angiographypt_PT
dc.subjectSuperficial vascular complexpt_PT
dc.subjectIPL/2021/DiffMeDiME_ESTeSLpt_PT
dc.titleFoveal avascular zone area measurement in diabetic patients: superficial, deep or combined retinal vascular complex?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage104743pt_PT
oaire.citation.titleMicrovascular Researchpt_PT
oaire.citation.volume157pt_PT
person.familyNameCardoso Pereira
person.familyNameCarolino
person.familyNameCamacho
person.givenNameBruno André
person.givenNameElisabete
person.givenNamePedro
person.identifier.ciencia-id1E1C-EB74-EB5E
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.ciencia-id271F-B4E1-014E
person.identifier.orcid0000-0003-4955-1770
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0002-2986-5652
person.identifier.ridF-1012-2015
person.identifier.scopus-author-id25821697000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication38b0604f-dd74-4a8a-921c-0ac2eb4fdcc1
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublicationc41e9c52-157e-4375-8005-b609cfc374e7
relation.isAuthorOfPublication.latestForDiscovery38b0604f-dd74-4a8a-921c-0ac2eb4fdcc1

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