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Genetic profile of rotavirus type A in children under 5 years old in Africa: a systematic review of prevalence

2024-02Journal article Open access
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dc.contributor.authorMiranda, Sandra
dc.contributor.authorTonin, Fernanda
dc.contributor.authorPinto-Sousa, Carlos
dc.contributor.authorFortes-Gabriel, Elsa
dc.contributor.authorBrito, Miguel
dc.date.accessioned2024-02-05T10:39:33Z
dc.date.available2024-02-05T10:39:33Z
dc.date.issued2024-02
dc.description.abstractHuman type A rotavirus (RV-A) is world-recognized as the major pathogen causing viral gastroenteritis in children under 5 years of age. The literature indicates a substantial increase in the diversity of rotavirus strains across continents, especially in Africa, which can pose significant challenges including an increase in disease burden and a reduction of vaccines’ effectiveness. However, few studies have mapped the variety of circulating virus strains in different regions, which may hamper decisions on epidemiological surveillance and preventive public health measures. Thus, we aimed to compile the most updated available evidence on the genetic profile of RV-A among children in Africa and determine the prevalence of different genotypes according to the geographical regions using a broad systematic review. Systematic searches were performed in PubMed, Scopus, Web of Science, and Scielo without language, time limits, or geographical restrictions within the African continent. We selected full-text peer-reviewed articles assessing the genetic profile (i.e., genotyping) of RV-A in children up to 5 years old in Africa. Overall, 682 records were retrieved, resulting in 75 studies included for evidence synthesis. These studies were published between 1999 and 2022, and were conducted in 28 countries from the five African regions, and 48% of the studies were carried out for 24 months or more. Most studies (n = 55; 73.3%) evaluated RV-A cases before the introduction of the vaccines, while around 20% of studies (n = 13) presented data after the vaccine approval in each country. Only seven (9.3%) studies compared evidence from both periods (pre- and post-vaccine introduction). Genotyping methods to assess RV-A varied between RT-PCR, nested, or multiplex RT-PCR, testing only the most common P and G-types. We observed G1 and P[8] to be the most prevalent strains in Africa, with values around 31% and 43%, respectively. Yet if all the genotypes with the following highest prevalence were added ((G1 + G2, G3, G9) and (P[8] + P[6], P[4])), these figures would represent 80% and 99% of the total prevalence. The combination of G1P[8] was the most reported in the studies (around 22%). This review study demonstrated an increased strain diversity in the past two decades, which could represent a challenge to the efficacy of the current vaccine.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMiranda S, Tonin FS, Pinto-Sousa C, Fortes-Gabriel E, Brito M. Genetic profile of rotavirus type A in children under 5 years old in Africa: a systematic review of prevalence. Viruses. 2024;16(2):243.pt_PT
dc.identifier.doi10.3390/v16020243pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17046
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1999-4915/16/2/243pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectRotaviruspt_PT
dc.subjectGenetic profilept_PT
dc.subjectChildrenpt_PT
dc.subjectSystematic reviewpt_PT
dc.subjectAfricapt_PT
dc.titleGenetic profile of rotavirus type A in children under 5 years old in Africa: a systematic review of prevalencept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPage243pt_PT
oaire.citation.titleVirusespt_PT
oaire.citation.volume16pt_PT
person.familyNameTonin
person.familyNameBrito
person.givenNameFernanda
person.givenNameMiguel
person.identifier.ciencia-idD01C-C700-9411
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0003-4262-8608
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridO-2050-2017
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id56085115800
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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