Synovial biopsy in a case of nivolumab-induced arthritis

Costa, Roberto Pereira da; Pinho, Mafalda; Patrocínio, João; Torres, Sofia; Ferreira, Cristina; Fonseca, João Eurico; Khmelinskii, Nikita

http://hdl.handle.net/10400.21/22351

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Authors

Costa, Roberto Pereira da

Abstract(s)

Immune checkpoint inhibitors (ICIs) are valuable therapeutic weapons against cancer that potentiate a T cell-mediated immune response. Nivolumab is an ICI that targets the PD-1 receptor. Rheumatic immune-related adverse events (irAEs), which are induced by ICIs, occur in 10% of cases. However, their pathogenesis remains unclear. Synovial biopsy has allowed for a better understanding of the underlying mechanisms of different arthropathies. Key message: Synovial biopsy has a role in understanding the aetiopathogenesis of immune checkpoint inhibitor-induced arthritis.

Keywords

Nivolumab-induced arthritis Synovial biopsy

URI

http://hdl.handle.net/10400.21/22351

Citation

Pereira da Costa R, Pinho M, Patrocínio J, Torres S, Ferreira C, Fonseca JE, et al. Synovial biopsy in a case of nivolumab-induced arthritis. Clin Exp Rheumatol. 2025 Sep 2. Epub ahead of print.