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Genotoxicity assessment of a selected cytostatic drug mixture in human lymphocytes: a study based on concentrations relevant for occupational exposure

2018-02Artigo científico Acesso restrito
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dc.contributor.authorGajski, Goran
dc.contributor.authorLadeira, Carina
dc.contributor.authorGerić, Marko
dc.contributor.authorGaraj-Vrhovac, Vera
dc.contributor.authorViegas, Susana
dc.date.accessioned2017-12-26T23:08:14Z
dc.date.available2017-12-26T23:08:14Z
dc.date.issued2018-02
dc.descriptionEste trabalho foi financiado pelo Concurso Anual para Projetos de Investigação, Desenvolvimento, Inovação e Criação Artística (IDI&CA) 2016 do Instituto Politécnico de Lisboa. Código de referência: IPL/2016/CYTO_VET_ESTeSLpt_PT
dc.description.abstractCytostatic drugs are highly cytotoxic agents used in cancer treatment and although their benefit is unquestionable, they have been recognized as hazardous to healthcare professionals in occupational settings. In a working environment, simultaneous exposure to cytostatics may occur creating a higher risk than that of a single substance. Hence, the present study evaluated the combined cyto/genotoxicity of a mixture of selected cytostatics with different mechanisms of action (MoA; 5-fluorouracil, cyclophosphamide, and paclitaxel) towards human lymphocytes in vitro at a concentration range relevant for occupational as well as environmental exposure. The results suggest that the selected cytostatic drug mixture is potentially cyto/genotoxic and that it can induce cell and genome damage even at low concentrations. This indicates not only that such mixture may pose a risk to cell and genome integrity, but also that single compound toxicity data are not sufficient for the prediction of toxicity in a complex working environment. The presence of drugs in different amounts and with different MoA suggests the need to study the relationship between the presence of genotoxic components in the mixture and the resulting effects, taking into account the MoA of each component by itself. Therefore, this study provides new data sets necessary for scientifically-based risk assessments of cytostatic drug mixtures in occupational as well as environmental settings.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGajski G, Ladeira C, Gerić M, Garaj-Vrhovac V, Viegas S. Genotoxicity assessment of a selected cytostatic drug mixture in human lymphocytes: a study based on concentrations relevant for occupational exposure. Environ Res. 2018;161(Feb):26-34.pt_PT
dc.identifier.doi10.1016/j.envres.2017.10.044pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/7799
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEste trabalho foi financiado pelo Concurso Anual para Projetos de Investigação, Desenvolvimento, Inovação e Criação Artística (IDI&CA) 2016 do Instituto Politécnico de Lisboa. Código de referência: IPL/2016/CYTO_VET_ESTeSLpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0013935117316675pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subject5-fluorouracilpt_PT
dc.subjectCyclophosphamidept_PT
dc.subjectCyto/genotoxicitypt_PT
dc.subjectHuman lymphocytespt_PT
dc.subjectPaclitaxelpt_PT
dc.subjectIPL/2016/CYTO_VET_ESTeSLpt_PT
dc.titleGenotoxicity assessment of a selected cytostatic drug mixture in human lymphocytes: a study based on concentrations relevant for occupational exposurept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage34pt_PT
oaire.citation.startPage26pt_PT
oaire.citation.titleEnvironmental Researchpt_PT
oaire.citation.volume161pt_PT
person.familyNameLadeira
person.familyNameViegas
person.givenNameCarina
person.givenNameSusana
person.identifier144237
person.identifier248817
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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