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Accuracy of COVID-19 diagnostic tests via infrared spectroscopy: a systematic review and meta-analysis

2025-02Journal article Embargoed access
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dc.contributor.authorCobre, Alexandre de Fátima
dc.contributor.authorFachi, Mariana Millan
dc.contributor.authorDomingues, Karime Zeraik Abdalla
dc.contributor.authorLazo, Raul Edison Luna
dc.contributor.authorFerreira, Luana Mota
dc.contributor.authorTonin, Fernanda
dc.contributor.authorPontarolo, Roberto
dc.date.accessioned2024-11-13T12:18:54Z
dc.date.embargo2026-11-13
dc.date.issued2025-02
dc.description.abstractThis study aims to synthesize the evidence on the accuracy parameters of COVID-19 diagnosis methods using infrared spectroscopy (FTIR). A systematic review with searches in PubMed and Embase was performed (September 2023). Studies reporting data on test specificity, sensitivity, true positive, true negative, false positive, and false negative using different human samples were included. Meta-analysis of accuracy estimates with 95 % confidence intervals and area under the ROC Curve (AUC) were conducted (Meta-Disc 1.4.7). Seventeen studies were included - all of them highlighted regions 650-1800 cm-1 and 2300-3900 cm-1 as most important for diagnosing COVID-19. The FTIR technique presented high sensitivity [0.912 (95 %CI, 0.878-0.939), especially in vaccinated [0.959 (CI95 %, 0.908-0.987)] compared to unvaccinated [0.625 (CI95 %, 0.584-0.664)] individuals for COVID-19. Overall specificity was also high [0.886 (95 %CI, 0.855-0.912), with increased rates in vaccinated [0.884 (CI95 %, 0.819-0.932)] than in unvaccinated [0.667 (CI95 %, 0.629-0.704)] patients. These findings reveal that FTIR is an accurate technique for detecting SARS-CoV-2 infection in different biological matrices with advantages including low cost, rapid and environmentally friendly with minimal preparation analyses. This could lead to an easy implementation of this technique in practice as a screening tool for patients with suspected COVID-19, especially in low-income countries.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCobre AF, Fachi MM, Domingues KZA, Lazo REL, Ferreira LM, Tonin FS, et al. Accuracy of COVID-19 diagnostic tests via infrared spectroscopy: a systematic review and meta-analysis. Spectrochim Acta A Mol Biomol Spectrosc. 2025;327:125337.pt_PT
dc.identifier.doi10.1016/j.saa.2024.125337pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17895
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1386142524015038pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectSARS-CoV-2pt_PT
dc.subjectCoronaviruspt_PT
dc.subjectEvidencept_PT
dc.subjectFTIRpt_PT
dc.subjectInfrared spectroscopypt_PT
dc.subjectSensitivitypt_PT
dc.subjectSpecificitypt_PT
dc.titleAccuracy of COVID-19 diagnostic tests via infrared spectroscopy: a systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage125337pt_PT
oaire.citation.titleSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopypt_PT
oaire.citation.volume327pt_PT
person.familyNameTonin
person.givenNameFernanda
person.identifier.ciencia-idD01C-C700-9411
person.identifier.orcid0000-0003-4262-8608
person.identifier.ridO-2050-2017
person.identifier.scopus-author-id56085115800
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication.latestForDiscovery61ded30e-ecec-4b3e-b953-2293e080ebdd

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