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HBM4EU chromates study: usefulness of measurement of blood chromium levels in the assessment of occupational Cr(VI) exposure

2022-11Journal article Open access
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dc.contributor.authorNdaw, Sophie
dc.contributor.authorLeso, Veruscka
dc.contributor.authorBousoumah, Radia
dc.contributor.authorRémy, Aurélie
dc.contributor.authorBocca, Beatrice
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGodderis, Lode
dc.contributor.authorHardy, Emilie
dc.contributor.authorJanasik, Beata
dc.contributor.authorvan Nieuwenhuyse, An
dc.contributor.authorPinhal, Hermínia
dc.contributor.authorPoels, Katrien
dc.contributor.authorPorras, Simo P.
dc.contributor.authorRuggieri, Flavia
dc.contributor.authorSantonen, Tiina
dc.contributor.authorSantos, Sílvia Reis
dc.contributor.authorScheepers, Paul.T.J.
dc.contributor.authorSilva, Maria João
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorViegas, Susana
dc.contributor.authorWasowicz, Wojciech
dc.contributor.authorIavicoli, Ivo
dc.contributor.authorAimonen, Kukka
dc.contributor.authorAntoine, Guillaume
dc.contributor.authorAnzion, Rob
dc.contributor.authorBurgart, Manuella
dc.contributor.authorCattaneo, Andrea
dc.contributor.authorCavallo, Domenico M.
dc.contributor.authorCosta, Alcina
dc.contributor.authorDe Palma, Giuseppe
dc.contributor.authorDenis, Flavien
dc.contributor.authorForte, Giovanni
dc.contributor.authorGambelunghe, Angela
dc.contributor.authorHanser, Ogier
dc.contributor.authorLadeira, Carina
dc.contributor.authorLeese, Elisabeth
dc.contributor.authorLehtinen, Risto
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorLovreglio, Piero
dc.contributor.authorMajery, Nicole
dc.contributor.authorMarsan, Philippe
dc.contributor.authorMelczer, Mathieu
dc.contributor.authorMiranda, Armandida
dc.contributor.authorRibeiro, Edna
dc.contributor.authorSchaefers, Françoise
dc.contributor.authorSenofonte, Marta
dc.contributor.authorSeuanes, Filomena
dc.contributor.authorvan Dael, Maurice
dc.contributor.authorVelin, Riitta
dc.date.accessioned2022-06-27T15:12:28Z
dc.date.available2022-06-27T15:12:28Z
dc.date.issued2022-11
dc.description.abstractOccupational exposures to hexavalent chromium (Cr(VI)) can occur in welding, hot working stainless steel processing, chrome plating, spray painting, and coating activities. Recently, within the human biomonitoring for Europe initiative (HBM4EU), a study was performed to assess the suitability of different biomarkers to assess the exposure to Cr(VI) in various job tasks. Blood-based biomarkers may prove useful when more specific information on systemic and intracellular bioavailability is necessary. To this aim, concentrations of Cr in red blood cells (RBC-Cr) and in plasma (P–Cr) were analyzed in 345 Cr(VI) exposed workers and 175 controls to understand how these biomarkers may be affected by variable levels of exposure and job procedures. Compared to controls, significantly higher RBC-Cr levels were observed in both plating and paint application workers, but not in welders, while all the 3 groups had significantly greater P–Cr concentrations. RBC-Cr and P–Cr in chrome platers showed a high correlation with Cr(VI) in inhalable dust, outside respiratory protective equipment (RPE), while such correlation could not be determined in welders. In platers, the use of RPE had a significant impact on the relationship between blood biomarkers and Cr(VI) in inhalable and respirable dust. Low correlations between P–Cr and RBC-Cr may reflect a difference in kinetics. This study showed that Cr-blood-based biomarkers can provide information on how workplace exposure translates into systemic availability of Cr(III) (extracellular, P–Cr) and Cr(VI) (intracellular, RBC-Cr). Further studies are needed to fully appreciate their use in an occupational health and safety context.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNdaw S, Leso V, Bousoumah R, Rémy A, Bocca B, Duca RC, HBM4EU chromates study team [Ladeira C, Ribeiro E]. HBM4EU chromates study: usefulness of measurement of blood chromium levels in the assessment of occupational Cr(VI) exposure. Environ Res. 2022;214(Pt 1):113758.pt_PT
dc.identifier.doi10.1016/j.envres.2022.113758pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14748
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEuropean Union’s Horizon 2020 - Grant agreement No 733032pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0013935122010854pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectRed blood cells chromiumpt_PT
dc.subjectPlasma chromiumpt_PT
dc.subjectBiological monitoringpt_PT
dc.subjectWorkplacept_PT
dc.subjectElectroplatingpt_PT
dc.subjectWeldingpt_PT
dc.titleHBM4EU chromates study: usefulness of measurement of blood chromium levels in the assessment of occupational Cr(VI) exposurept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issuePt 1pt_PT
oaire.citation.startPage113758pt_PT
oaire.citation.titleEnvironmental Researchpt_PT
oaire.citation.volume214pt_PT
person.familyNameViegas
person.familyNameLadeira
person.familyNameRibeiro
person.givenNameSusana
person.givenNameCarina
person.givenNameEdna
person.identifier248817
person.identifier144237
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1316-7750
person.identifier.ridI-4053-2012
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id36463788000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublicationa571bf34-bcda-49ca-b5cb-4cdecbb3d9c7
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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