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Sickle cell disease and gut health: the influence of intestinal parasites and the microbiome on Angolan children

2024-07Journal article Open access
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dc.contributor.authorDelgadinho, Mariana
dc.contributor.authorGinete, Catarina
dc.contributor.authorSantos, Brígida
dc.contributor.authorVasconcelos, Jocelyne Neto
dc.contributor.authorArez, Ana Paula
dc.contributor.authorBrito, Miguel
dc.date.accessioned2024-07-24T10:22:21Z
dc.date.available2024-07-24T10:22:21Z
dc.date.issued2024-07
dc.descriptionThis work was funded by the following grants: IPL/IDI&CA2022/ParasitSCD, FCT/Aga Khan (project no. 330842553), and FCT/MCTES (https://doi.org/10.54499/UIDB/05608/2020 and https://doi.org/10.54499/UIDP/05608/2020)-H&TRC. Author M.D. has received financial support from an FCT research fellowship UI/BD/150705/2020 (https://doi.org/10.54499/UI/BD/150705/2020).pt_PT
dc.description.abstractParasitic infections are a common problem in developing countries and can intensify morbidity in patients with sickle cell disease (SCD), increasing the severity of anemia and the need for transfusions. It has been demonstrated that both helminths and protozoa can affect gut microbiome composition. On the other hand, the presence of specific bacterial communities can also influence parasite establishment. Considering this, our aim was to associate the presence of intestinal parasites with the results of hematological analyses and microbiome composition evaluations in a population of Angolan children with and without SCD. A total of 113 stool samples were collected, and gut microbiome analysis was performed using 16S sequencing and real-time PCR to detect eight different intestinal parasites. In our population, more than half of children (55%) had at least one parasitic infection, and of these, 43% were co-infected. Giardia intestinalis and Ascaris lumbricoides were more frequently found in children from the rural area of Bengo. Moreover, SCD children with ascariasis exhibited higher values of leukocytes and neutrophils, whereas the total hemoglobin levels were lower. In regards to the gut microbiome, the presence of intestinal parasites lowered the prevalence of some beneficial bacteria, namely: Lactobacillus, Bifidobacterium, Cuneatibacter, Bacteroides uniformis, Roseburia, and Shuttleworthia. This study presents the prevalence of several intestinal parasites in a high-risk transmission area with scarce information and opens new perspectives for understanding the interaction between parasites, the microbiome, and SCD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDelgadinho M, Ginete C, Santos B, Vasconcelos JN, Arez AP, Brito M. Sickle cell disease and gut health: the influence of intestinal parasites and the microbiome on Angolan children. Int J Mol Sci. 2024;25(13):7258.pt_PT
dc.identifier.doi10.3390/ijms25137258pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17585
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationIPL/IDI&CA2022/ParasitSCDpt_PT
dc.relationFCT/Aga Khan (project no. 330842553)pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/25/13/7258pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAscaris lumbricoidespt_PT
dc.subjectBifidobacteriumpt_PT
dc.subjectGiardia intestinalispt_PT
dc.subjectLactobacilluspt_PT
dc.subjectParasitic infectionspt_PT
dc.subjectGut microbiomept_PT
dc.subjectSickle cell diseasept_PT
dc.subjectChildrenpt_PT
dc.subjectAngolapt_PT
dc.subjectIPL/IDI&CA2022/ParasitSCDpt_PT
dc.subjectFCT/Aga Khan (project no. 330842553)pt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleSickle cell disease and gut health: the influence of intestinal parasites and the microbiome on Angolan childrenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue13pt_PT
oaire.citation.startPage7258pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume25pt_PT
person.familyNameNeves Delgadinho
person.familyNameHonrado Ginete
person.familyNameBrito
person.givenNameMariana Isabel
person.givenNameAna Catarina
person.givenNameMiguel
person.identifierCAJ-5082-2022
person.identifier.ciencia-id231E-02E3-D9A9
person.identifier.ciencia-id8715-F62E-1E0F
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0003-0586-9154
person.identifier.orcid0000-0002-2334-782X
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationca55aab6-9a58-4f79-ab79-20513414099f
relation.isAuthorOfPublicationdfb2fbba-17ff-42fb-905a-fcfc8f326e1c
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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