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Synthesis of organometallic Ruthenium(II) complexes with strong activity against several human canceer cell lines

2012-09Journal article Restricted access
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dc.contributor.authorMorais, Tânia S.
dc.contributor.authorSilva, Tiago J. L.
dc.contributor.authorMarques, Fernanda
dc.contributor.authorRobalo, Maria Paula
dc.contributor.authorAvecilla, Fernando
dc.contributor.authorMadeira, Paulo J. Amorim
dc.contributor.authorMendes, Paulo J. G.
dc.contributor.authorSantos, Isabel
dc.contributor.authorGarcia, M. Helena
dc.date.accessioned2015-09-08T15:45:59Z
dc.date.available2015-09-08T15:45:59Z
dc.date.issued2012-09
dc.description.abstractA new family of "RuCp" (Cp=eta(5)-C5H5) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PD. IC50 values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data.por
dc.identifier.doi10.1016/j.jinorgbio.2012.04.014
dc.identifier.issn0162-0134
dc.identifier.urihttp://hdl.handle.net/10400.21/5127
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevier Science INCpor
dc.relationFundação para a Ciência e Tecnologia - PTDC/QUI/66148/2006
dc.relationFundação para a Ciência e Tecnologia - PTDC/Qui-qui/101187/2008
dc.relationFundação para a Ciência e Tecnologia - PEst-OE/QUI/UI0536/2011
dc.relationFundação para a Ciência e Tecnologia - REDE/1501/REM/2005
dc.relationFCT - SFRH/BD/45871/2008
dc.relationFCT - SFRH/BD/64309/2009
dc.subjectRuthenium(II)
dc.subjectCyclopentadienyl
dc.subjectHeteroaromatic ligand
dc.subjectOrganometallic
dc.subjectEffective core potentials
dc.subjectCyclopentadiennyl derivative complexes
dc.subjectMolecular calculations
dc.subjectHeteroaromatic ligands
dc.subjectAnticancer agents
dc.subjectInhibition
dc.subjectGrowth
dc.subjectCytotoxicity
dc.subjectChemistry
dc.subjectElements
dc.titleSynthesis of organometallic Ruthenium(II) complexes with strong activity against several human canceer cell linespor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNew York
oaire.citation.endPage74por
oaire.citation.startPage65por
oaire.citation.titleJournal of Inorganic Biochemistrypor
oaire.citation.volume114por
person.familyNameRobalo
person.familyNameAnselmo Viegas Garcia
person.givenNameMaria Paula
person.givenNameMaria Helena
person.identifierH-2175-­2013
person.identifier.ciencia-idE11C-A704-9C18
person.identifier.ciencia-id5414-9AEF-4194
person.identifier.orcid0000-0002-8200-6910
person.identifier.orcid0000-0002-4344-2218
person.identifier.ridB-2002-2012
person.identifier.scopus-author-id9269662100
person.identifier.scopus-author-id6507884466
rcaap.rightsclosedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication823a9498-17ab-451f-bb8f-56338643ac0c
relation.isAuthorOfPublicationddef2398-fb7d-4551-a9fe-71c411d1d706
relation.isAuthorOfPublication.latestForDiscovery823a9498-17ab-451f-bb8f-56338643ac0c

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