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Orientador(es)
Resumo(s)
A new family of "RuCp" (Cp=eta(5)-C5H5) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PD. IC50 values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data.
Descrição
Palavras-chave
Ruthenium(II) Cyclopentadienyl Heteroaromatic ligand Organometallic Effective core potentials Cyclopentadiennyl derivative complexes Molecular calculations Heteroaromatic ligands Anticancer agents Inhibition Growth Cytotoxicity Chemistry Elements
Contexto Educativo
Citação
Editora
Elsevier Science INC