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The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative review

2023-03Journal article Open access
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dc.contributor.authorFernandes, Nádia
dc.contributor.authorAraújo, Marta Castro
dc.contributor.authorLança, Carla
dc.date.accessioned2023-04-21T11:41:10Z
dc.date.available2023-04-21T11:41:10Z
dc.date.issued2023-03
dc.description.abstractAge-related macular degeneration (AMD) is a chronic progressive ocular disease and the main cause of severe visual impairment in the elderly. Vitamin D deficiency may be a risk factor for AMD. Additionally, current evidence suggests dietary advice of increasing the consumption of polyphenols, which may have antioxidant and anti-inflammatory properties. The aim of this review was to describe the roles of vitamin D levels and polyphenols in the management of AMD. The results of this review showed mixed evidence regarding the protective effect of vitamin D against AMD. Polyphenols (flavonoids group, curcumin, and resveratrol) seem to play an important role as angiogenesis inhibitors, but their effect on AMD is still unclear. Vitamin D and polyphenols may both play an important role as nutritional modifiable protective factors that reduce the risk of AMD progression. However, more research is necessary to better understand the roles of vitamin D and polyphenols in different stages of the disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFernandes N, Araújo MC, Lança C. The roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative review. Future Pharmacol. 2023;3(1):317-28.pt_PT
dc.identifier.doi10.3390/futurepharmacol3010020pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15931
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2673-9879/3/1/20pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOphthalmologypt_PT
dc.subjectAge macular degenerationpt_PT
dc.subjectVitamin Dpt_PT
dc.subject25-Hydroxyvitamin D serumpt_PT
dc.subjectPolyphenolspt_PT
dc.subjectNutritionpt_PT
dc.subjectEye healthcarept_PT
dc.subjectRetinapt_PT
dc.subjectChoroidpt_PT
dc.titleThe roles of vitamin D and polyphenols in the management of age-related macular degeneration: a narrative reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage328pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage317pt_PT
oaire.citation.titleFuture Pharmacologypt_PT
oaire.citation.volume3pt_PT
person.familyNameLança
person.givenNameCarla
person.identifier.ciencia-id601A-6412-BF2F
person.identifier.orcid0000-0001-9918-787X
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0320b455-ee19-4670-8bf2-10dce9de1bec
relation.isAuthorOfPublication.latestForDiscovery0320b455-ee19-4670-8bf2-10dce9de1bec

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