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The genotoxicity of an organic solvent mixture: a human biomonitoring study and translation of a real-scenario exposure to in vitro

2020-10Journal article Restricted access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorGajski, Goran
dc.contributor.authorMeneses, Márcia
dc.contributor.authorGerić, Marko
dc.contributor.authorViegas, Susana
dc.date.accessioned2020-07-29T10:19:18Z
dc.date.available2020-07-29T10:19:18Z
dc.date.issued2020-10
dc.descriptionEuropean Cooperation in Science and Technology (CA COST Actions CA15132 – hCOMET and CA16113 – CliniMARK).pt_PT
dc.description.abstractThis study aimed to evaluate occupational exposure to a styrene and xylene mixture through environmental exposure assessment and identify the potential genotoxic effects through biological monitoring. Secondly, we also exposed human peripheral blood cells in vitro to both xylene and styrene either alone or in a mixture at concentrations found in occupational settings in order to understand their mechanism of action. The results obtained by air monitoring were below the occupational exposure limits for both substances. All biomarkers of effect, except for nucleoplasmic bridges, had higher mean values in workers (N = 17) compared to the corresponding controls (N = 17). There were statistically significant associations between exposed individuals and the presence of nuclear buds and oxidative damage. As for in vitro results, there was no significant influence on primary DNA damage in blood cells as evaluated by the comet assay. On the contrary, we did observe a significant increase of micronuclei and nuclear buds, but not nucleoplasmic bridges upon in vitro exposure. Taken together, both styrene and xylene have the potential to induce genomic instability either alone or in combination, showing higher effects when combined. The obtained data suggested that thresholds for individual chemicals might be insufficient for ensuring the protection of human health.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationLadeira C, Gajski G, Meneses M, Gerić M, Viegas S. The genotoxicity of an organic solvent mixture: a human biomonitoring study and translation of a real-scenario exposure to in vitro. Regul Toxicol Pharmacol. 2020;116:ID104726.pt_PT
dc.identifier.doi10.1016/j.yrtph.2020.104726pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12110
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEuropean Cooperation in Science and Technology (CA COST Actions CA15132 – hCOMET)pt_PT
dc.relationEuropean Cooperation in Science and Technology (CA16113 – CliniMARK)pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0273230020301525pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectStyrenept_PT
dc.subjectXylenept_PT
dc.subjectMixturespt_PT
dc.subjectOccupational exposurept_PT
dc.subjectMonitoringpt_PT
dc.subjectIn vitropt_PT
dc.subjectCA COST Actions CA15132 – hCOMETpt_PT
dc.subjectCA16113 – CliniMARKpt_PT
dc.titleThe genotoxicity of an organic solvent mixture: a human biomonitoring study and translation of a real-scenario exposure to in vitropt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage104726pt_PT
oaire.citation.startPageID104726pt_PT
oaire.citation.titleRegulatory Toxicology and Pharmacologypt_PT
oaire.citation.volume116pt_PT
person.familyNameLadeira
person.familyNameViegas
person.givenNameCarina
person.givenNameSusana
person.identifier144237
person.identifier248817
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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