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IL23R polymorphisms influence phenotype and response to therapy in patients with ulcerative colitis

2014-01Journal article Restricted access
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dc.contributor.authorCravo, Marília
dc.contributor.authorFerreira, P. A.
dc.contributor.authorSousa, P.
dc.contributor.authorSantos, Paula Moura dos
dc.contributor.authorVelho, S.
dc.contributor.authorTavares, Lourdes
dc.contributor.authorde Deus, J. R.
dc.contributor.authorMinistro, P.
dc.contributor.authorPeixe, P.
dc.contributor.authorCorreia, L. A.
dc.contributor.authorVelosa, J. F.
dc.contributor.authorMaio, R. F.
dc.contributor.authorBrito, Miguel
dc.date.accessioned2014-01-03T21:30:55Z
dc.date.available2014-01-03T21:30:55Z
dc.date.issued2014-01
dc.description.abstractObjective - We aimed to identify the clinical and genetic [IL23 receptor (IL23R) single nucleotide polymorphisms (SNPs)] predictors of response to therapy in patients with ulcerative colitis. Patients and methods - A total of 174 patients with ulcerative colitis, 99 women and 75 men, were included. The mean age of the patients was 47±15 years and the mean disease duration was 11±9 years. The number of patients classified as responders (R) or nonresponders (NR) to several therapies was as follows: 110 R and 53 NR to mesalazine (5-ASA), 28 R and 20 NR to azathioprine (AZT), 18 R and 7 NR to infliximab. Clinical and demographic variables were recorded. A total of four SNPs were studied: IL23R G1142A, C2370A, G43045A, and G9T. Genotyping was performed by real-time PCR using Taqman probes. Results - Older patients were more prone to respond to 5-ASA (P=0.004), whereas those with pancolitis were less likely to respond to such therapies (P=0.002). Patients with extraintestinal manifestations (EIMs) were less likely to respond to 5-ASA (P=0.001), AZT (P=0.03), and corticosteroids (P=0.06). Carriers of the mutant allele for IL23R SNPs had a significantly higher probability of developing EIMs (P<0.05), a higher probability of being refractory to 5-ASA (P<0.03), but a higher likelihood of responding to AZT (P=0.05). A significant synergism was observed between IL23R C2370A and EIMs with respect to nonresponse to 5-ASA (P=0.03). Conclusion - Besides extent of disease and age at disease onset, the presence of EIMs may be a marker of refractoriness to 5-ASA, corticosteroids, and AZT. IL23R SNPs are associated both with EIMs and with nonresponse to 5-ASA and corticosteroids.por
dc.identifier.citationCravo ML, Ferreira PA, Sousa P, Moura-Santos P, Velho S, Brito M, et al. IL23R polymorphisms influence phenotype and response to therapy in patients with ulcerative colitis. Eur J Gastroenterol Hepatol. 2014;26(1):26-32.por
dc.identifier.issn1473-5687
dc.identifier.urihttp://hdl.handle.net/10400.21/3065
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherLippincott Williams & Wilkinspor
dc.subjectIL23R polymorphismspor
dc.subjectUlcerative colitispor
dc.subjectSingle nucleotide polymorphismspor
dc.titleIL23R polymorphisms influence phenotype and response to therapy in patients with ulcerative colitispor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage32por
oaire.citation.startPage26por
oaire.citation.titleEuropean Journal of Gastroenterology & Hepatologypor
oaire.citation.volume26por
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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