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Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory gd T cell subsets

2013-09Journal article Open access
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dc.contributor.authorSchmolka, Nina
dc.contributor.authorSerre, Karine
dc.contributor.authorGrosso, Ana R.
dc.contributor.authorRei, Margarida
dc.contributor.authorPennington, Daniel J.
dc.contributor.authorGomes, Anita Q.
dc.contributor.authorSilva-Santos, Bruno
dc.date.accessioned2014-08-26T15:13:48Z
dc.date.available2014-08-26T15:13:48Z
dc.date.issued2013-09
dc.description.abstractTwo distinct subsets of γδ T cells that produce interleukin 17 (IL-17) (CD27(-) γδ T cells) or interferon-γ (IFN-γ) (CD27(+) γδ T cells) develop in the mouse thymus, but the molecular determinants of their functional potential in the periphery remain unknown. Here we conducted a genome-wide characterization of the methylation patterns of histone H3, along with analysis of mRNA encoding transcription factors, to identify the regulatory networks of peripheral IFN-γ-producing or IL-17-producing γδ T cell subsets in vivo. We found that CD27(+) γδ T cells were committed to the expression of Ifng but not Il17, whereas CD27(-) γδ T cells displayed permissive chromatin configurations at loci encoding both cytokines and their regulatory transcription factors and differentiated into cells that produced both IL-17 and IFN-γ in a tumor microenvironment.por
dc.identifier.citationSchmolka N, Serre K, Grosso AR, Rei M, Pennington DJ, Gomes AQ, Silva-Santos B. Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets. Nat Immunol. 2013;14(10):1093-100.por
dc.identifier.doi10.1038/ni.2702
dc.identifier.urihttp://hdl.handle.net/10400.21/3768
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherNaturepor
dc.relation.publisherversionhttp://www.immunology.kserre.net/docs/2013-Nature-Immunol-Epigenetic-on-gd-T-cells-.pdfpor
dc.subjectCell differentiationpor
dc.subjectCytokinespor
dc.subjectGene expression profilingpor
dc.subjectGene expression regulationpor
dc.subjectMethylationpor
dc.subjectT-Lymphocyte subsetspor
dc.subjectTh1 cellspor
dc.subjectTh17 cellspor
dc.subjectTranscriptomepor
dc.titleEpigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory gd T cell subsetspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1100por
oaire.citation.startPage1093por
oaire.citation.titleNature Immunologypor
oaire.citation.volume14por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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