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What do we know about the α/β for prostate cancer?

dc.contributor.authorOliveira, S. M.
dc.contributor.authorTeixeira, Nuno
dc.contributor.authorFernandes, Lisete
dc.date.accessioned2013-04-23T10:12:32Z
dc.date.available2013-04-23T10:12:32Z
dc.date.issued2012-06
dc.description.abstractSince last decade, the debate on the parameter which reflects prostate cancer sensitivity to fractionation in a radiotherapy treatment, the α/β, has become extensive. Unlike most tumors, the low labeling indices (LI) and large potential doubling time that characterize the prostate tumor led some authors to consider that it may behave as a late responding tissue. So far, the existing studies with regard to this subject point to a low value of α/β, around 2.7 Gy, which may be considered as a therapeutic gain in relation to surrounding normal tissues by using fewer and larger fractions. The aim of this paper is to review several estimates that have been made in the last few years regarding the prostate cancer α/β both from clinical and experimental data, as well as the set of factors that have potentially influenced these evaluations.por
dc.identifier.citationOliveira SM, Teixeira N, Fernandes L. What do we know about the α/β for prostate cancer? Med Phys. 2012;39(6):3189-201.por
dc.identifier.issn0094-2405
dc.identifier.urihttp://hdl.handle.net/10400.21/2449
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAmerican Association of Physicists in Medicinepor
dc.relation.publisherversionhttp://online.medphys.org/resource/1/mphya6/v39/i6/p3189_s1por
dc.subjectOncologypor
dc.subjectCancerpor
dc.subjectRadiotherapypor
dc.subjectSensitivitypor
dc.subjectTumourspor
dc.subjectProstate cancerpor
dc.subjectRadiobiologypor
dc.subjectAlpha/beta ratiopor
dc.subjectDose fractionationpor
dc.titleWhat do we know about the α/β for prostate cancer?por
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3201por
oaire.citation.startPage3189por
oaire.citation.titleMedical Physicspor
oaire.citation.volume39por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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