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Corneal subbasal nerve plexus evaluation by in vivo confocal microscopy in multiple sclerosis: a potential new biomarker

2021-04Journal article Open access
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dc.contributor.authorFernandes, Diogo
dc.contributor.authorLuís, Maria
dc.contributor.authorCardigos, Joana
dc.contributor.authorXavier, Catarina
dc.contributor.authorAlves, Marta
dc.contributor.authorPapoila, Ana Luísa
dc.contributor.authorCunha, João Paulo
dc.contributor.authorFerreira, Joana Correia
dc.date.accessioned2021-08-04T14:37:34Z
dc.date.available2024-08-04T00:30:20Z
dc.date.issued2021-04
dc.description.abstractPurpose/Aim: Our study aims to evaluate corneal subbasal nerve plexus morphology by in vivo corneal confocal microscopy (CCM) in Multiple Sclerosis (MS) patients and to explore its potential ability to distinguish between MS patients and healthy subjects. Materials and methods: Cross-sectional study, including 60 MS patients and 22 healthy subjects. Expanded Disability Status Scale (EDSS) was used to assess neurological disability. All participants underwent full ophthalmology evaluation, CCM and optical coherence tomography (OCT). Corneal nerve fibre density (CNFD), branch density (CNBD), fibre length (CNFL) and fibre tortuosity (CNFT) were analysed. Generalized additive regression models were used to analyse the data. Results: Compared to controls, MS patients had lower CNFD, CNBD and CNFL (p < .001) and higher CNFT (p = .002). The area under the ROC curve to distinguish MS patients from healthy controls with CNFD and CNBD was 0.84 (95%CI: 0.75 to 0.93; 95%CI: 0.75 to 0.92, respectively). A nonlinear association between EDSS and CNFD was found, with an initial density increase followed by a significant decrease until more severe disability status. EDSS was associated with CNFL and CNBD, with values being significantly lower for patients with an EDSS > 2.5 (-2.06 mm/mm2; 95%CI: -3.84 to -0.28; p = .027 and -8.70 branches/mm2; 95%CI: -14.69 to -2.71; p = .006, respectively). Optic neuritis (ON) history did not influence CCM parameters. Conclusions: Our results confirm CCM parameters' potential to differentiate MS patients from healthy subjects, not being influenced by a previous ON history. A significant relationship between the patient's disability and corneal nerve morphology was also found.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFernandes D, Luís M, Cardigos J, Xavier C, Cunha JP, Ferreira JT, et al. Corneal subbasal nerve plexus evaluation by in vivo confocal microscopy in multiple sclerosis: a potential new biomarker. Curr Eye Res. 2021;46(10):1452-9.pt_PT
dc.identifier.doi10.1080/02713683.2021.1904509pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13623
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relation.publisherversionhttps://www.tandfonline.com/doi/abs/10.1080/02713683.2021.1904509?journalCode=icey20pt_PT
dc.subjectOphthalmologypt_PT
dc.subjectOrthopticspt_PT
dc.subjectCorneal subbasal nerve plexuspt_PT
dc.subjectConfocal microscopypt_PT
dc.subjectExpanded Disability Status Scalept_PT
dc.subjectMultiple sclerosispt_PT
dc.subjectOptical coherence tomographypt_PT
dc.titleCorneal subbasal nerve plexus evaluation by in vivo confocal microscopy in multiple sclerosis: a potential new biomarkerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1459pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1452pt_PT
oaire.citation.titleCurrent Eye Researchpt_PT
oaire.citation.volume46pt_PT
person.familyNameFerreira
person.givenNameJoana Correia
person.identifier.orcid0000-0001-5382-3367
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication5969938b-ed5e-4aaa-b2c7-e85dad5c801b
relation.isAuthorOfPublication.latestForDiscovery5969938b-ed5e-4aaa-b2c7-e85dad5c801b

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