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Treating sickle cell disease in resource-limited sub-Saharan Africa: recent strategies and recommendations in addressing the gaps for the provision of evidence-based management

2025-06Journal article Open access
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorBrito, Miguel
dc.contributor.authorGinete, Catarina
dc.contributor.authorOfakunrin, Akinyemi
dc.contributor.authorDiaku-Akinwumi, Ijeoma
dc.contributor.authorInusa, Baba Psalm
dc.date.accessioned2025-06-05T12:12:13Z
dc.date.available2025-06-05T12:12:13Z
dc.date.issued2025-06
dc.descriptionWe acknowledge the WHO permission for figure usage in the paper. Authors acknowledge the benefit of the ARISE project, which received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 824021.
dc.description.abstractIntroduction: The management of Sickle cell disease (SCD) in sub-Saharan Africa (SSA) suffers from the lack of universal infant and population screening, inadequate access to standard treatment, and poor public health prioritization amidst unstable political systems. Areas covered: The state of evidence-based management of SCD in SSA was investigated, including the sustainability of international funding agencies. Expert opinion: Current efforts are fragmentary along language lines; sometimes driven by the funder's objectives and not the national agenda. The review highlighted the role of internal and external partnerships, such as SPARCO, ARISE, and CONSA, as well as technology-based support for the implementation of evidence-based care for SCD. We advocate for increased funding to implement SCD comprehensive care in line with the WHO SCD Framework for Primary, Secondary, Tertiary, and Specialist Comprehensive Care at the state and national level. To achieve this objective, it is important that SCD, as a leading non-communicable disease in Africa, be mandated as a standing agenda for the National Council of Ministers at the African Union, the WHO, and other regional bodies in Africa.eng
dc.identifier.citationBrito M, Ginete C, Ofakunrin A, Diaku-Akinwumi I, Inusa BP. Treating sickle cell disease in resource-limited sub-Saharan Africa: recent strategies and recommendations in addressing the gaps for the provision of evidence-based management. Expert Rev Hematol. 2025;18(6):447-62.
dc.identifier.doi10.1080/17474086.2025.2500599
dc.identifier.issn1747-4086
dc.identifier.issn1747-4094
dc.identifier.urihttp://hdl.handle.net/10400.21/21909
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor and Francis
dc.relation.hasversionhttps://www.tandfonline.com/doi/full/10.1080/17474086.2025.2500599
dc.relation.ispartofExpert Review of Hematology
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSickle cell disease
dc.subjectSub-Saharan Africa
dc.subjectAnemia
dc.subjectAntimalarial prophylaxis
dc.subjectBlood transfusion
dc.subjectGenetic counseling
dc.subjectHealth financing
dc.subjectHydroxyurea
dc.subjectMalaria prophylaxis
dc.subjectNewborn screening
dc.subjectPenicillin V
dc.titleTreating sickle cell disease in resource-limited sub-Saharan Africa: recent strategies and recommendations in addressing the gaps for the provision of evidence-based managementeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage462
oaire.citation.issue6
oaire.citation.startPage447
oaire.citation.titleExpert Review of Hematology
oaire.citation.volume18
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBrito
person.familyNameHonrado Ginete
person.givenNameMiguel
person.givenNameAna Catarina
person.identifier.ciencia-id231F-F341-7E93
person.identifier.ciencia-id8715-F62E-1E0F
person.identifier.orcid0000-0001-6394-658X
person.identifier.orcid0000-0002-2334-782X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublicationdfb2fbba-17ff-42fb-905a-fcfc8f326e1c
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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