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A review of neuro-ophthalmological manifestations of human coronavirus infection

2020-10Journal article Open access
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dc.contributor.authorLuís, Maria Elisa
dc.contributor.authorHipólito-Fernandes, Diogo
dc.contributor.authorMota, Catarina
dc.contributor.authorMaleita, Diogo
dc.contributor.authorXavier, Catarina
dc.contributor.authorMaio, Tiago
dc.contributor.authorCunha, João Paulo
dc.contributor.authorFerreira, Joana Tavares
dc.date.accessioned2020-12-07T22:20:05Z
dc.date.available2020-12-07T22:20:05Z
dc.date.issued2020-10
dc.description.abstractIntroduction: Human coronavirus (HCoVs) are a group of viruses with recognized neurotropic and neuroinvasive capabilities. The reports on the neurological and ocular findings are increasing day after day and several central and peripheral neurological manifestations are already described. However, none specifically describes the neuro-ophthalmological manifestation of HCoVs. This is the first article specifically reviewing neuro-ophthalmological manifestations of HCoVs infection. Methods: PubMed and Google Scholar databases were searched using the keywords: coronaviridae, coronavirus, COVID-19, SARS-CoV-2, SARS-CoV-1, MERS, ocular, ophthalmology, ophthalmological, neuro-ophthalmology, neurological, manifestations. A manual search through the reference lists of relevant articles was also performed. There were no restrictions concerning language or study type and publications not yet printed but available online were considered. Results: Coronavirus eye involvement is not frequent and includes mostly typical viral follicular conjunctivitis. Recently, retinal anatomical alterations were described using optic coherence tomography. Neuro-ophthalmological symptoms and signs can appear isolated or associated with neurological syndromes. The manifestations include headache, ocular pain, visual impairment, diplopia, cranial nerve palsies secondary to Miller Fisher syndrome, Guillain-Barré syndrome, encephalitis, and nystagmus. Conclusion: Neurological and neuro-ophthalmological syndromes, symptoms, and signs should not be neglected and a complete ophthalmological examination of these patients should be performed to fully describe ocular manifestations related to HCoVs. We believe that major ocular and neuro-ophthalmological manifestations reports lack due to safety issues concerning detailed ophthalmological examination; on the other hand, in a large number of cases, the presence of life-threatening coronavirus disease hinders ocular examination and ophthalmologist's visit to the intensive care unit.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLuís ME, Hipólito-Fernandes D, Mota C, Maleita D, Xavier C, Ferreira JT. A review of neuro-ophthalmological manifestations of human coronavirus infection. Eye Brain. 2020;12:129-37.pt_PT
dc.identifier.doi10.2147/EB.S268828pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12421
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDove Presspt_PT
dc.relation.publisherversionhttps://www.dovepress.com/a-review-of-neuro-ophthalmological-manifestations-of-human-coronavirus-peer-reviewed-article-EBpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHuman coronaviruspt_PT
dc.subjectNeurotropicpt_PT
dc.subjectNeuro-ophthalmologicalpt_PT
dc.subjectOphthalmologypt_PT
dc.subjectManifestationspt_PT
dc.titleA review of neuro-ophthalmological manifestations of human coronavirus infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage137pt_PT
oaire.citation.startPage129pt_PT
oaire.citation.titleEye and Brainpt_PT
oaire.citation.volume12pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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