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Cynara scolymus L. A promising Mediterranean extract for topical anti-aging prevention

2017-12Journal article Restricted access
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dc.contributor.authorMarques, P.
dc.contributor.authorMarto, J.
dc.contributor.authorGonçalves, L.M.
dc.contributor.authorPacheco, Rita
dc.contributor.authorFitas, M.
dc.contributor.authorPinto, P.
dc.contributor.authorSerralheiro, M.L.M.
dc.contributor.authorRibeiro, H.
dc.date.accessioned2017-09-28T10:29:40Z
dc.date.available2017-09-28T10:29:40Z
dc.date.issued2017-12
dc.description.abstractCynara scolymus L. (CS), usually known as globe artichoke, is a Mediterranean plant with antioxidant properties due to its content of polyphenols, including caffeoylquinic and dicaffeoylquinic acids. The use of bioactive ingredients or phytochemicals extracted from plant tissues in cosmetics is increasing, thus artichoke extract due to its promising constituents can be incorporated in topical formulations. The aim of this study was the chemical characterization of different CS extracts in order to investigate the antioxidant and the sun protection potential in topical formulations. Aqueous extracts were analyzed by HPLC to quantify target compounds, such as cynarin, chlorogenic acid and cynaroside. Antioxidant activity by DPPH assay and ROS scavenging activity in HaCaT cells, as well as cytotoxicity assays and sun protection factor were assessed. The results showed that CS extract and CSC fraction, one of the purified fractions, were rich in polyphenols and presented antioxidant and photoprotective activity. Then, both fractions were incorporated in two topical formulations: O/W emulsion and hydrogel. Physicochemical characterization, microbiological control, cytotoxicity assays and ROS scavenging activity in HaCaT cells were performed to ensure the quality, safety and efficacy of the products developed. In vivo studies, Human Repeat Insult Patch Testing and an assay to determine their antioxidant capacity, were also performed. Besides the excellent antioxidant and photoprotective activity, the final formulations proved to be also suitable and safe for topical use.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMARQUES, P. [et al] - Cynara scolymus L.: A promising Mediterranean extract for topical anti-aging prevention. Industrial Crops and Products. ISSN: 0926-6690. Vol. 109, (2017), pp. 699-706pt_PT
dc.identifier.doihttps://doi.org/10.1016/j.indcrop.2017.09.033pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/7394
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://ac.els-cdn.com/S0926669017306313/1-s2.0-S0926669017306313-main.pdf?_tid=4c4778ea-a435-11e7-b0b9-00000aacb362&acdnat=1506593628_dbbb72c6230c02aaebe10dab54e79131pt_PT
dc.subjectCynara scolymus L.pt_PT
dc.subjectGlobe artichokept_PT
dc.subjectPlant extractpt_PT
dc.subjectTopical formulationpt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectSun protection factorpt_PT
dc.titleCynara scolymus L. A promising Mediterranean extract for topical anti-aging preventionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage706pt_PT
oaire.citation.startPage699pt_PT
oaire.citation.titleIndustrial Crops and Productspt_PT
oaire.citation.volume109pt_PT
person.familyNamePacheco
person.givenNameRita
person.identifier1022927
person.identifier.ciencia-id9F13-D310-B5A3
person.identifier.orcid0000-0001-5192-3006
person.identifier.ridC-3062-2012
person.identifier.scopus-author-id8853708300
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd6907c0a-3f8f-431c-acf2-0b257692f0d4
relation.isAuthorOfPublication.latestForDiscoveryd6907c0a-3f8f-431c-acf2-0b257692f0d4

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