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Antifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sources

2016-10Journal article Restricted access
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dc.contributor.authorSabino, Raquel
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorVeríssimo, Cristina
dc.contributor.authorMartinez, Marife
dc.contributor.authorClemons, Karl V.
dc.contributor.authorStevens, David A.
dc.date.accessioned2016-12-21T17:25:24Z
dc.date.available2016-12-21T17:25:24Z
dc.date.issued2016-10
dc.description.abstractSome environmental Aspergillus spp. isolates have been described as resistant to antifungals, potentially causing an emerging medical problem. In the present work, the antifungal susceptibility profile of 41 clinical and 134 environmental isolates of Aspergillus was determined using the CLSI microdilution method. The aim of this study was to compare environmental and clinical isolates with respect to their susceptibility, and assess the potential implications for therapy of isolates encountered in different environments. To our knowledge, this is the first report comparing antifungal susceptibility profiles of Aspergillus collected from different environmental sources (poultries, swineries, beach sand, and hospital environment). Significant differences were found in the distribution of the different species sections for the different sources. Significant differences were also found in the susceptibility profile of the different Aspergillus sections recovered from the various sources. Clear differences were found between the susceptibility of clinical and environmental isolates for caspofungin, amphotericin B and posaconazole, with clinical isolates showing overall greater susceptibility, except for caspofungin. In comparison to clinical isolates, hospital environmental isolates showed significantly less susceptibility to amphotericin B and posaconazole. These data indicate that species section identity and the site from which the isolate was recovered influence the antifungal susceptibility profile, which may affect initial antifungal choices.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSabino R, Carolino E, Veríssimo C, Martinez M, Clemons KV, Stevens DA. Antifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sources. Med Mycol. 2016;54(7):740-56.pt_PT
dc.identifier.doi10.1093/mmy/myw024pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/6651
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relation.publisherversionhttp://mmy.oxfordjournals.org/content/early/2016/05/03/mmy.myw024.longpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAspergilluspt_PT
dc.subjectAntifungal susceptibilitypt_PT
dc.titleAntifungal susceptibility of 175 Aspergillus isolates from various clinical and environmental sourcespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage756pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage740pt_PT
oaire.citation.titleMedical Mycologypt_PT
oaire.citation.volume54pt_PT
person.familyNameSabino
person.familyNameCarolino
person.givenNameRaquel Filipa Pinheiro
person.givenNameElisabete
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.orcid0000-0001-6585-7775
person.identifier.orcid0000-0003-4165-7052
person.identifier.ridF-1012-2015
person.identifier.scopus-author-id35796067600
person.identifier.scopus-author-id25821697000
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcf64684a-fb92-4421-91da-14fb15462fad
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublication.latestForDiscoverycf64684a-fb92-4421-91da-14fb15462fad

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