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Exposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approach

2018-08Journal article Open access
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dc.contributor.authorViegas, Susana
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorNunes, Carla
dc.contributor.authorOsteresch, Bernd
dc.contributor.authorTwarużek, Magdalena
dc.contributor.authorKosicki, Robert
dc.contributor.authorGrajewski, Jan
dc.contributor.authorMartins, Carla
dc.contributor.authorAlvito, Paula
dc.contributor.authorAlmeida, Ana
dc.contributor.authorViegas, Carla
dc.date.accessioned2018-09-17T15:47:33Z
dc.date.available2018-09-17T15:47:33Z
dc.date.issued2018-08
dc.description.abstractMycotoxins are toxic mold metabolites that can persist in environment long after the fungi species responsible for their production disappear. Critical workplace for mycotoxins presence has already been studied and nowadays it is possible to recognize that exposure to mycotoxins through inhalation occurs due to their presence in dust. This study aimed to assess occupational co-exposure to multiple mycotoxins in a fresh bread dough company, an occupational setting not studied until now. Occupational exposure assessment to mycotoxins was done using a LC-MS/MS urinary multi-biomarker approach. Twenty-one workers and nineteen individuals that were used as controls participated in the study. Workers/controls (spot-urine) and environment (settled dust) samples were collected and analyzed. Concerning workers group, DON-GlcA, and OTA were the most prevalent biomarkers (>LOD), 66% and 90.5%, respectively. In the control group, OTA was also one of the most detected (68%) followed by CIT (58%) and DON-GlcA (58%). DON was the mycotoxin measured in high amounts in the settled dust sample (58.2 ng/g). Both workers and controls are exposed to several mycotoxins simultaneously. The workers group, due to their high contact with flour dust, revealed a higher exposure to DON. Considering these results, risk management measures must be applied including specific and adequate health surveillance programs in order to avoid exposure and consequently the associated health consequences.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationViegas S, Assunção R, Nunes C, Osteresch B, Almeida A, Viegas C, et al. Exposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approach. Toxins (Basel). 2018 Aug 23;10(9):342.pt_PT
dc.identifier.doi10.3390/toxins10090342pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/8859
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttp://www.mdpi.com/2072-6651/10/9/342pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectMycotoxinspt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectFungi metabolitespt_PT
dc.subjectPortugalpt_PT
dc.titleExposure assessment to mycotoxins in a Portuguese fresh bread dough company by using a multi-biomarker approachpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue9pt_PT
oaire.citation.startPage342pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume10pt_PT
person.familyNameViegas
person.familyNameViegas
person.givenNameSusana
person.givenNameCarla
person.identifier248817
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-idEE1E-C639-D70F
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0002-1545-6479
person.identifier.ridI-4053-2012
person.identifier.ridB-7217-2013
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id55443609700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublicationb5fa5da4-50c3-4b88-ae20-1bc63cb485f7
relation.isAuthorOfPublication.latestForDiscoveryb5fa5da4-50c3-4b88-ae20-1bc63cb485f7

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