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The effect of hydroxyurea in the gut microbiome of Angolan children with sickle cell disease

2022-06Conference object Open access
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dc.contributor.authorDelgadinho, Mariana
dc.contributor.authorGinete, Catarina
dc.contributor.authorFernandes, C.
dc.contributor.authorSantos, Brígida
dc.contributor.authorVasconcelos, J.
dc.contributor.authorBrito, Miguel
dc.date.accessioned2022-08-23T14:37:01Z
dc.date.available2022-08-23T14:37:01Z
dc.date.issued2022-06
dc.descriptionFCT/Aga Khan (project no. 330842553).pt_PT
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractPurpose: Sickle cell disease (SCD) is one of the most prevalent genetic disorders, affecting around 20 to 25 million individuals throughout the world. In Sub-Saharan Africa, where it is more prevalent, it can contribute to up to 80% of under-5 mortality. Clinical manifestations of SCD are very heterogeneous and the intestinal microbiome has recently been reported to be crucial in the modulation of inflammation, cell adhesion, and induction of aged neutrophils, which are key interveners of recurrent vaso-occlusive crises. Since gut bacteria can regulate aged neutrophils, defects in either the integrity of the intestinal walls or a chronic disequilibrium of the microbiota are very likely to emerge in SCD patients. Moreover, it has been suggested that Hydroxyurea (HU), the most common treatment for SCD, shows a multimodal action and may reduce microbiome dysbiosis and aged neutrophils. In this context, we aimed to understand how SCD and HU treatment modulates the microbiome and if these changes could be related to disease severity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDelgadinho M, Ginete C, Fernandes C, Santos B, Vasconcelos J, Brito M. The effect of hydroxyurea in the gut microbiome of Angolan children with sickle cell disease. In: 4th Global Congress on Sickle Cell Disease [hybrid congress], Paris (France), June 16-18, 2022. PI-03. HemaSphere. 2022;6(Aug):10.pt_PT
dc.identifier.doi10.1097/01.HS9.0000872872.99697.fbpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14934
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationFCT/Aga Khan (project no. 330842553)pt_PT
dc.relation.publisherversionhttps://journals.lww.com/hemasphere/Fulltext/2022/08004/PI_03__THE_EFFECT_OF_HYDROXYUREA_IN_THE_GUT.17.aspxpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectSickle cell diseasept_PT
dc.subjectHydroxyureapt_PT
dc.subjectChildrenpt_PT
dc.subjectAngolapt_PT
dc.subjectFCT_Aga Khan (project no. 330842553)pt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleThe effect of hydroxyurea in the gut microbiome of Angolan children with sickle cell diseasept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage10pt_PT
oaire.citation.startPage10pt_PT
oaire.citation.titleHemaSpherept_PT
oaire.citation.volume6pt_PT
person.familyNameNeves Delgadinho
person.familyNameHonrado Ginete
person.familyNameBrito
person.givenNameMariana Isabel
person.givenNameAna Catarina
person.givenNameMiguel
person.identifierCAJ-5082-2022
person.identifier.ciencia-id231E-02E3-D9A9
person.identifier.ciencia-id8715-F62E-1E0F
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0003-0586-9154
person.identifier.orcid0000-0002-2334-782X
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationca55aab6-9a58-4f79-ab79-20513414099f
relation.isAuthorOfPublicationdfb2fbba-17ff-42fb-905a-fcfc8f326e1c
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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