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Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells

2005-06Journal article Open access
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dc.contributor.authorGonçalves, João
dc.contributor.authorMalta-Vacas, Joana
dc.contributor.authorLouis, Monette
dc.contributor.authorBrault, Laurent
dc.contributor.authorBagrel, Denyse
dc.contributor.authorMonteiro, Carolino
dc.contributor.authorBrito, Miguel
dc.date.accessioned2014-01-04T18:46:53Z
dc.date.available2014-01-04T18:46:53Z
dc.date.issued2005-06
dc.description.abstractThe histone deacetylase inhibitors sodium butyrate (NaBu) and trichostatin A (TSA) exhibit anti-proliferative activity by causing cell cycle arrest and apoptosis. The mechanisms by which NaBu and TSA cause apoptosis and cell cycle arrest are not yet completely clarified, although these agents are known to modulate the expression of several genes including cell-cycle- and apoptosis-related genes. The enzymes involved in the process of translation have important roles in controlling cell growth and apoptosis, and several of these translation factors have been described as having a causal role in the development of cancer. The expression patterns of the translation mechanism, namely of the elongation factors eEF1A1 and eEF1A2, and of the termination factors eRF1 and eRF3, were studied in the breast cancer cell line MCF-7 by real-time quantitative reverse transcription-polymerase chain reaction after a 24-h treatment with NaBu and TSA. NaBu induced inhibition of translation factors' transcription, whereas TSA caused an increase in mRNA levels. Thus, these two agents may modulate the expression of translation factors through different pathways. We propose that the inhibition caused by NaBu may, in part, be responsible for the cell cycle arrest and apoptosis induced by this agent in MCF-7 cells.por
dc.identifier.citationGonçalves J, Malta-Vacas J, Louis M, Brault L, Bagrel D, Brito M, et al. Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells. Clin Chem Lab Med. 2005;43(2):151-6.por
dc.identifier.issn1434-6621
dc.identifier.urihttp://hdl.handle.net/10400.21/3075
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherDe Gruyterpor
dc.relation.publisherversionhttps://www.degruyter.com/view/j/cclm.2005.43.issue-2/cclm.2005.025/cclm.2005.025.xmlpor
dc.subjectPharmacologypor
dc.subjectAntineoplastic agentspor
dc.subjectApoptosispor
dc.subjectBreast neoplasmspor
dc.subjectButyratespor
dc.subjectCell cyclepor
dc.subjectEnzyme inhibitorspor
dc.subjectGene expression regulationpor
dc.subjectGenes, Neoplasmpor
dc.subjectHistone deacetylase inhibitorspor
dc.subjectHydroxamic acidspor
dc.subjectPeptide chain elongation, Translationalpor
dc.subjectProtein biosynthesispor
dc.subjectTumor cells, Culturedpor
dc.titleModulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cellspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage156por
oaire.citation.startPage151por
oaire.citation.titleClinical Chemistry and Laboratory Medicinepor
oaire.citation.volume43por
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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