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Advisor(s)
Abstract(s)
Aflatoxins were first isolated about 40 years ago afier outbreaks of disease and death in turkeys and cancer in rainbow trout fed with rations formulated from peanut and
cottonseed meals. These toxins are secondary metabolites produced under certain conditions of temperature, p14 and
humidity predominantiy by Aspergilius flavus and Aspergilius parasiticus fungi species. Among 18 different types of aflatoxins identified, major members are aflatoxin B1, B2, G1 and G2. Aflatoxin B1 (AFB1) is normaily predominant in cultures as well as in food products. AFB1 was shown to be genotoxic and a potent hepatocarcinogen. This mycotoxin is metabolized by the mixed function oxidase system to a number of hydroxylated metabolites including the 8,9-epoxide. The latter is considered to be the ultimate carcinogen that reacts with cellular deoxyribonucleic acid (DNA) and proteins to form covalent adducts.
Description
Keywords
Environmental health Occupational health Swinery Aflatoxin B1
Citation
Viegas S, Veiga L, Figueiredo P, Almeida A, Carolino E, Viegas C. Occupational exposure to Aflatoxin B1 in Portuguese swine farms. In SHO 2013 - International Symposium on Occupational Safety and Hygiene, Guimarães (Portugal), 14th-15th February 2013. Oral presentation.