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Algorithm to assess the presence of Aspergillus fumigatus resistant strains: the case of Norwegian sawmills

dc.contributor.authorViegas, Carla
dc.contributor.authorAlmeida, Beatriz
dc.contributor.authorAranha Caetano, Liliana
dc.contributor.authorAfanou, Anani
dc.contributor.authorStraumfors, Anne
dc.contributor.authorVeríssimo, Cristina
dc.contributor.authorGonçalves, Paulo
dc.contributor.authorSabino, Raquel
dc.date.accessioned2020-08-25T15:56:03Z
dc.date.available2020-08-25T15:56:03Z
dc.date.issued2022-05
dc.descriptionIPL/2018/WasteFRPD_ESTeSL. Project nº 23222 (02/SAICT/2016).pt_PT
dc.descriptionUIDB/05608/2020. UIDP/05608/2020.pt_PT
dc.description.abstractAssociation between selection pressure caused by the use of azole fungicides in sawmills and the development of fungal resistance has been described. The aim of this study was to implement an algorithm to assess the presence of Aspergillus section Fumigati resistant strains in sawmills. Eighty-six full-shift inhalable dust samples were collected from eleven industrial sawmills in Norway. Different culture media were used and molecular identification to species level in Aspergillus section Fumigati was done by calmodulin sequencing and TR34/L98H and TR46/Y121F/T289A mutations were screened by real-time PCR assay and confirmed by cyp51A sequencing. Six Fumigati isolates were identified as A. fumigatus sensu stricto and two of these grew on azole-supplemented media and were further analyzed by real-time PCR. One was confirmed to be a TR34/L98H mutant. The obtained results reinforce the need to assess the presence of A. fumigatus sensu stricto resistant isolates at other workplaces with fungicide pressure.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationViegas C, Almeida B, Caetano LA, Afanou A, Straumfors A, Veríssimo C, et al. Algorithm to assess the presence of Aspergillus fumigatus resistant strains: the case of Norwegian sawmills. Int J Environ Health Res. 2022;32(5):963-71.pt_PT
dc.identifier.doi10.1080/09603123.2020.1810210pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12189
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationIPL/2018/WasteFRPD_ESTeSLpt_PT
dc.relationProject nº 23222 (02/SAICT/2016)pt_PT
dc.relationHealth and Technology Research Center
dc.relationHealth and Technology Research Center
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/09603123.2020.1810210pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectSection Fumigatipt_PT
dc.subjectAspergillus fumigatus resistant isolatespt_PT
dc.subjectCross-resistancept_PT
dc.subjectFungicide pressurept_PT
dc.subjectNorwaypt_PT
dc.subjectIPL/2018/WasteFRPD_ESTeSLpt_PT
dc.subjectProject nº 23222 (02/SAICT/2016)pt_PT
dc.subjectUIDB/05608/2020pt_PT
dc.subjectUIDP/05608/2020pt_PT
dc.titleAlgorithm to assess the presence of Aspergillus fumigatus resistant strains: the case of Norwegian sawmillspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth and Technology Research Center
oaire.awardTitleHealth and Technology Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05608%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F05608%2F2020/PT
oaire.citation.endPage9pt_PT
oaire.citation.endPage971pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.startPage963pt_PT
oaire.citation.titleInternational Journal of Environmental Health Researchpt_PT
oaire.citation.volume32pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameViegas
person.familyNameAranha Caetano
person.givenNameCarla
person.givenNameLiliana
person.identifier.ciencia-idEE1E-C639-D70F
person.identifier.ciencia-id9716-9DAC-532A
person.identifier.orcid0000-0002-1545-6479
person.identifier.orcid0000-0003-1496-2609
person.identifier.ridB-7217-2013
person.identifier.scopus-author-id55443609700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb5fa5da4-50c3-4b88-ae20-1bc63cb485f7
relation.isAuthorOfPublication6517c656-f913-4f54-8682-77c2856c9e4c
relation.isAuthorOfPublication.latestForDiscovery6517c656-f913-4f54-8682-77c2856c9e4c
relation.isProjectOfPublication76f1ec64-a9ed-464a-8a86-b96f3b11c498
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relation.isProjectOfPublication.latestForDiscovery76f1ec64-a9ed-464a-8a86-b96f3b11c498

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