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Occupational exposure to Cr(VI) in Finland in 1980–2016 and related lung cancer risk assessment

2022-12Artigo científico Acesso aberto
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dc.contributor.authorMahiout, Selma
dc.contributor.authorKiilunen, Mirja
dc.contributor.authorVermeire, Theo
dc.contributor.authorViegas, Susana
dc.contributor.authorWoutersen, Marjolijn
dc.contributor.authorSantonen, Tiina
dc.date.accessioned2022-10-17T09:56:16Z
dc.date.available2024-10-17T00:30:22Z
dc.date.issued2022-12
dc.description.abstractOccupational exposure to hexavalent chromium [Cr(VI)], a known lung carcinogen, remains a relevant concern. When performing exposure assessment for risk assessment, biomonitoring is an important tool, reflecting actual internal exposure of workers. Here, we present total urinary chromium (U-Cr) biomonitoring data from several occupational sectors, spanning 1980-2016 (n > 42,000). Based on this data, we estimated lifelong (40-year) occupational lung cancer risks in the Cr-plating and welding sectors. We used published regression formulas to relate internal (U-Cr) and external Cr(VI) inhalation exposures, allowing risk assessment based on a published lung cancer dose response. Generally, measured U-Cr levels decreased considerably over the study period. The highest U-Cr P95 levels (representing realistic worst-case) were measured in 1980-1989 in casters, maintenance workers, and welders (40-45 μg/L). By 2010-2016, the U-Cr P95 had decreased to ≤9.5 μg/L in all studied sectors. Lifelong external Cr(VI) exposure estimation for 1980-2019 was 0.16-0.32 mg/m3 x year for platers and 1.03 mg/m3 x year for welders. Worst-case lifelong lung cancer relative risk (RR) estimates were 1.28-1.56 for platers and 2.80 for welders; attributable risks (AR) were 22-36% for platers and 64% for welders. Uncertainties that may have impacted the risk assessment are discussed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMahiout S, Kiilunen M, Vermeire T, Viegas S, Woutersen M, Santonen T. Occupational exposure to Cr(VI) in Finland in 1980-2016 and related lung cancer risk assessment. Regul Toxicol Pharmacol. 2022;136:105276.pt_PT
dc.identifier.doi10.1016/j.yrtph.2022.105276pt_PT
dc.identifier.pmid36240957
dc.identifier.urihttp://hdl.handle.net/10400.21/15027
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0273230022001635pt_PT
dc.subjectHBM4EUpt_PT
dc.subjectHexavalent chromiumpt_PT
dc.subjectHuman biomonitoringpt_PT
dc.subjectLung cancerpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectRisk assessmentpt_PT
dc.subjectFinlandpt_PT
dc.titleOccupational exposure to Cr(VI) in Finland in 1980–2016 and related lung cancer risk assessmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage105276pt_PT
oaire.citation.startPage105276pt_PT
oaire.citation.titleRegulatory Toxicology and Pharmacologypt_PT
oaire.citation.volume136pt_PT
person.familyNameViegas
person.givenNameSusana
person.identifier248817
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id35270591500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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