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Diagnóstico de lesão renal aguda através da análise optoelectrónica de urina
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Abstract(s)
A Lesão Renal Aguda (LRA) é uma condição grave com elevado risco de progressão para Doença Renal Crónica (DRC), especialmente quando não detetada precocemente. Este trabalho investiga o uso de técnicas optoelectrónicas, nomeadamente a espectroscopia de fluorescência e Raman, como métodos inovadores e não invasivos para a identificação de biomarcadores em amostras de urina. A espectroscopia de fluorescência demonstrou-se altamente eficaz na deteção de padrões espectrais relacionados com biomarcadores como a creatinina, permitindo diferenciar claramente amostras de indivíduos saudáveis e de pacientes com DRC. Esta abordagem, ao fornecer informações detalhadas sobre a concentração e presença de biomarcadores na urina, tem o potencial de revolucionar o diagnóstico precoce de doenças renais, permitindo intervenções terapêuticas mais rápidas e precisas. Com base nos resultados obtidos, as técnicas optoelectrónicas mostram grande viabilidade para futuras aplicações clínicas no diagnóstico de LRA e DRC.
Abstract Acute Kidney Injury (AKI) poses a significant risk of progressing to Chronic Kidney Disease (CKD), especially when early detection is delayed. This study explores the use of optoelectronic techniques, particularly fluorescence and Raman spectroscopy, as innovative and non-invasive methods for identifying biomarkers in urine samples. Fluorescence spectroscopy proved highly effective in detecting spectral patterns associated with key biomarkers such as creatinine, enabling clear differentiation between healthy individuals and patients with CKD. By providing detailed insights into the concentration and presence of biomarkers in urine, this approach has the potential to revolutionize early renal disease diagnostics, allowing for faster and more precise therapeutic interventions. Based on the results, optoelectronic techniques demonstrate strong viability for future clinical applications in the diagnosis of AKI and CKD.
Abstract Acute Kidney Injury (AKI) poses a significant risk of progressing to Chronic Kidney Disease (CKD), especially when early detection is delayed. This study explores the use of optoelectronic techniques, particularly fluorescence and Raman spectroscopy, as innovative and non-invasive methods for identifying biomarkers in urine samples. Fluorescence spectroscopy proved highly effective in detecting spectral patterns associated with key biomarkers such as creatinine, enabling clear differentiation between healthy individuals and patients with CKD. By providing detailed insights into the concentration and presence of biomarkers in urine, this approach has the potential to revolutionize early renal disease diagnostics, allowing for faster and more precise therapeutic interventions. Based on the results, optoelectronic techniques demonstrate strong viability for future clinical applications in the diagnosis of AKI and CKD.
Description
Dissertação para obtenção do grau de Mestre em Engenharia Biomédica
Keywords
Lesão renal aguda Doença renal crónica Espectroscopia de fluorescência Espectroscopia Raman Biomarcadores Diagnóstico não invasivo Acute kidney injury Chronic kidney disease Fluorescence spectroscopy Raman spectroscopy Biomarkers Non-invasive diagnosis
Citation
MORENO, Ana Filipa Basílio – Diagnóstico de lesão renal aguda através da análise optoelectrónica de urina. Lisboa: Instituto Superior de Engenharia de Lisboa. 2024. Dissertação de Mestrado.