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5' and 3' UTR thymidylate synthase polymorphisms modulate the risk of colorectal cancer independently of the intake of methyl group donors

2008-09Journal article Open access
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dc.contributor.authorCarmona, Bruno
dc.contributor.authorGuerreiro, Catarina Sousa
dc.contributor.authorCravo, Marília
dc.contributor.authorLeitão, Carlos Nobre
dc.contributor.authorBrito, Miguel
dc.date.accessioned2014-01-04T18:17:37Z
dc.date.available2014-01-04T18:17:37Z
dc.date.issued2008-09
dc.description.abstractThymidylate synthase, as a rate-limiting step in DNA synthesis, catalyses the conversion of dUMP into dTMP using 5,10-methylenotetrahydrofolate as the methyl donor. Two polymorphisms have been described in this gene: a repeat polymorphism in the 5' promoter enhancer region (3R versus 2R) and a 6 bp deletion in the 3' unstranslated region. Both of these may affect protein levels. The present case control study was aimed at investigating the influence of these two polymorphisms on the development of colorectal cancer (CRC), as well as their potential interaction with folate, vitamin B6 and vitamin B12 intake. A total of 196 cases and 200 controls, matched for age and sex distribution, were included in the study. No association was found between CRC and the 28 bp repeat polymorphism, but it was observed that individuals with the 6 bp/del and del/del genotypes had a significantly lower risk of developing the disease (OR=0.47; 95% CI 0.30-0.72). A combined genotype (2R/2R; 6 bp/del+del/del) was also found, which was associated with an even lower risk of developing of the disease (OR=0.42; 95% CI 0.26-0.69). No significant interaction between these polymorphisms and vitamin intake was observed. These results indicate for the first time that the 6 bp/del allele might be a protective factor in the development of CRC, independent of the intake of methyl group donors.por
dc.identifier.citationCarmona B, Guerreiro C, Cravo M, Nobre-Leitão C, Brito M. 5' and 3' UTR thymidylate synthase polymorphisms modulate the risk of colorectal cancer independently of the intake of methyl group donors. Mol Med Rep. 2008;1(5):747-52.por
dc.identifier.issn1791-3004
dc.identifier.urihttp://hdl.handle.net/10400.21/3073
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpandidos Publicationspor
dc.relation.publisherversionhttp://www.spandidos-publications.com/mmr/1/5/747por
dc.subjectColorectal cancerpor
dc.subjectPolymorphismspor
dc.subjectThymidylatepor
dc.subjectDNA synthesispor
dc.title5' and 3' UTR thymidylate synthase polymorphisms modulate the risk of colorectal cancer independently of the intake of methyl group donorspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage752por
oaire.citation.startPage747por
oaire.citation.titleMolecular Medicine Reportspor
oaire.citation.volume1por
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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