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Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms

2022-06Journal article Open access
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dc.contributor.authorZegre, Miguel
dc.contributor.authorBarros, J.
dc.contributor.authorRibeiro, I. A.
dc.contributor.authorSantos, C
dc.contributor.authorCaetano, Liliana Aranha
dc.contributor.authorGonçalves, L.
dc.contributor.authorMonteiro, F. J.
dc.contributor.authorFerraz, M. P.
dc.contributor.authorBettencourt, A.
dc.date.accessioned2022-05-23T11:10:42Z
dc.date.available2024-05-23T00:30:17Z
dc.date.issued2022-06
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractNew strategies for the treatment of polymicrobial bone infections are required. In this study, the co-delivery of two antimicrobials by poly(D,L-lactic acid) (PDLLA) scaffolds was investigated in a polymicrobial biofilm model. PDLLA scaffolds were prepared by solvent casting/particulate leaching methodology, incorporating minocycline and voriconazole as clinically relevant antimicrobial agents. The scaffolds presented a sponge-like appearance, suitable to support cell proliferation and drug release. Single- and dual-species biofilm models of Staphylococcus aureus and Candida albicans were developed and characterized. S. aureus presented a higher ability to form single-species biofilms, compared to C. Albicans. Minocycline and voriconazole-loaded PDLLA scaffolds showed activity against S. aureus and C. Albicans single- and dual-biofilms. Ultimately, the cytocompatibility/functional activity of PDLLA scaffolds observed in human MG-63 osteosarcoma cells unveil their potential as a next-generation co-delivery system for antimicrobial therapy in bone infections.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZegre M, Barros J, Ribeiro IA, Santos C, Caetano LA, Gonçalves L, et al. Poly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilms. Int J Pharm. 2022;622:121832.pt_PT
dc.identifier.doi10.1016/j.ijpharm.2022.121832pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14652
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0378517322003878pt_PT
dc.subjectBone infectionpt_PT
dc.subjectPolymicrobial biofilmspt_PT
dc.subjectMinocyclinept_PT
dc.subjectVoriconazolept_PT
dc.subjectCo-deliverypt_PT
dc.subjectLocalized antibiotic deliverypt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titlePoly(DL-lactic acid) scaffolds as a bone targeting platform for the co-delivery of antimicrobial agents against S. aureus-C.albicans mixed biofilmspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage121832pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume622pt_PT
person.familyNameAranha Caetano
person.givenNameLiliana
person.identifier.ciencia-id9716-9DAC-532A
person.identifier.orcid0000-0003-1496-2609
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6517c656-f913-4f54-8682-77c2856c9e4c
relation.isAuthorOfPublication.latestForDiscovery6517c656-f913-4f54-8682-77c2856c9e4c

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