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Helminth infections and allergic diseases: systematic review and meta-analysis of the global literature

2022-06Journal article Open access
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dc.contributor.authorArrais, Margarete
dc.contributor.authorMaricoto, Tiago
dc.contributor.authorNwaru, Bright I.
dc.contributor.authorCooper, Philip J.
dc.contributor.authorGama, Jorge M.R.
dc.contributor.authorBrito, Miguel
dc.contributor.authorTaborda-Barata, Luis
dc.date.accessioned2022-01-27T12:09:07Z
dc.date.available2022-01-27T12:09:07Z
dc.date.issued2022-06
dc.description.abstractBackground: There is considerable research interest in the role of helminth infections in the development of allergic diseases. However, findings from previous studies are mixed. Existing systematic reviews of these studies are outdated. We performed a systematic review of the global literature on the association between helminth infections and development and clinical outcomes of allergic diseases. Methods: We searched Cochrane Library, MEDLINE, EMBASE, ISI Web of Science, PubMed, Global Index Medicus, Scielo, KoreaMed, Google Scholar, and Lilacs for studies published up to January 2020. We included observational epidemiological studies (cohort, case-control, and cross-sectional studies) of children and adults reporting associations between helminth infections and asthma, allergic rhinitis, eczema, and atopy. We performed a random-effects meta-analysis to summarize the effect estimates. Results: We included 80 studies with 99,967 participants. In the meta-analyses, we did not observe an overall association between helminth infections and allergic diseases. There was, however, evidence that Ascaris lumbricoides infections were associated with an increased risk of bronchial hyperreactivity in children (risk ratio, 1.41; 95% CI, 1.17-1.70; I2 = 50; P for I2 = .09), and were associated with an increased risk of atopy among helminth-infected adults (risk ratio, 1.37; 95% CI, 1.18-1.61; I2 = 52; P for I2 = .02). We found no study that addressed the association between helminth infection and clinical outcomes of allergic diseases. The overall strength of the underlying evidence was low to moderate. Conclusions: Helminth infections may increase the risk of bronchial hyperreactivity in children and atopy in adults. Well-designed longitudinal cohorts may help clarify potential causal associations between chronic helminth infections and allergic diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArrais M, Maricoto T, Nwaru BI, Gama JM, Brito M, Taborda-Barata L. Helminth infections and allergic diseases: systematic review and meta-analysis of the global literature. J Allergy Clin Immunol. 2022;149(6):2139-52.pt_PT
dc.identifier.doi10.1016/j.jaci.2021.12.777pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14213
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0091674921027354pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHelminthspt_PT
dc.subjectAsthmapt_PT
dc.subjectAllergic diseasept_PT
dc.subjectAtopypt_PT
dc.subjectRisk factorpt_PT
dc.titleHelminth infections and allergic diseases: systematic review and meta-analysis of the global literaturept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2152pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage2139pt_PT
oaire.citation.titleJournal of Allergy and Clinical Immunologypt_PT
oaire.citation.volume149pt_PT
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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