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Light and myopia: from epidemiological studies to neurobiological mechanisms

2021-12Journal article Open access
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dc.contributor.authorMuralidharan, Arumugam R.
dc.contributor.authorLança, Carla
dc.contributor.authorBiswas, Sayantan
dc.contributor.authorBarathi, Veluchamy A.
dc.contributor.authorShermaine, Low W.
dc.contributor.authorSeang-Mei, Saw
dc.contributor.authorMilea, Dan
dc.contributor.authorNajjar, Raymond P.
dc.date.accessioned2021-12-23T12:40:43Z
dc.date.available2021-12-23T12:40:43Z
dc.date.issued2021-12
dc.description.abstractMyopia is far beyond its inconvenience and represents a true, highly prevalent, sight-threatening ocular condition, especially in Asia. Without adequate interventions, the current epidemic of myopia is projected to affect 50% of the world population by 2050, becoming the leading cause of irreversible blindness. Although blurred vision, the predominant symptom of myopia, can be improved by contact lenses, glasses, or refractive surgery, corrected myopia, particularly high myopia, still carries the risk of secondary blinding complications such as glaucoma, myopic maculopathy, and retinal detachment, prompting the need for prevention. Epidemiological studies have reported an association between outdoor time and myopia prevention in children. The protective effect of time spent outdoors could be due to the unique characteristics (intensity, spectral distribution, temporal pattern, etc.) of sunlight that is lacking in artificial lighting. Concomitantly, studies in animal models have highlighted the efficacy of light and its components in delaying or even stopping the development of myopia and endeavoured to elucidate possible mechanisms involved in this process. In this narrative review, we (1) summarize the current knowledge concerning light modulation of ocular growth and refractive error development based on studies in human and animal models, (2) summarize potential neurobiological mechanisms involved in the effects of light on ocular growth and emmetropization and (3) highlight a potential pathway for the translational development of noninvasive light-therapy strategies for myopia prevention in children.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMuralidharan AR, Lança C, Biswas S, Barathi VA, Shermaine LW, Seang-Mei S, et al. Light and myopia: from epidemiological studies to neuroiological mechanisms. Ther Adv Ophthalmol. 2021;13:1-45.pt_PT
dc.identifier.doi10.1177/25158414211059246pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14095
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSagept_PT
dc.relationA∗STAR-JANSSEN World without disease (A∗JWWD) (18/4/91/00/099)pt_PT
dc.relation.publisherversionhttps://journals.sagepub.com/doi/full/10.1177/25158414211059246pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMyopiapt_PT
dc.subjectLightpt_PT
dc.subjectDopaminept_PT
dc.subjectAnimal modelpt_PT
dc.subjectNeurobiologypt_PT
dc.subjectOutdoor activitypt_PT
dc.titleLight and myopia: from epidemiological studies to neurobiological mechanismspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage251584142110592pt_PT
oaire.citation.titleTherapeutic Advances in Ophthalmologypt_PT
oaire.citation.volume13pt_PT
person.familyNameLança
person.givenNameCarla
person.identifier.ciencia-id601A-6412-BF2F
person.identifier.orcid0000-0001-9918-787X
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0320b455-ee19-4670-8bf2-10dce9de1bec
relation.isAuthorOfPublication.latestForDiscovery0320b455-ee19-4670-8bf2-10dce9de1bec

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